Now showing items 1-20 of 120

    2-Quinoxalinol Based Schiff Base Ligands in Copper(II)-Mediated C-H Activation 

    Li, Yuancheng (2012-08-01)
    As environment and energy issues become of increasing concern, so too does our awareness of the impacts of chemical industry. Numerous successful attempts toward “green” or “greener” chemistry have been made. Among these, ...

    8-Alkyl Adenines and Their Nucleoside Derivatives 

    Abouelghit, Maha (2011-07-28)
    S-adenosylhomocysteine hydrolase has become an important target in the design of antiviral drugs. It is the only known enzyme in eukaryotes that is responsible for the catabolism of S-adenosylhomocysteine into adenosine ...

    Activation and Inhibitor Studies on Methyl-Coenzyme M Reductase and Purification of a New Hydroxylamine Oxidoreductase from Methylomicrobium Album ATCC 33003 

    Yang, Na (2009-02-23)
    Methyl-coenzyme M reductase (MCR) catalyzes the formation of methane from methyl-coenzyme M (CH3-S-CoM) and coenzyme B (HS-CoB) in methanogenic archaea. In order to manage the overproduction of methane in the environment, ...

    Allylic Oxidation of Steroidal Compounds Using Vanadyl Acetylacetonate and Tert-butyl Hydroperoxide 

    Grainger, Wendell (2015-07-29)
    Allylic oxidation is an important reaction in steroid chemistry. Previously reported methods have various limits which do not apply when using vanadyl acetylacetonate and tert-butyl hydroperoxide. These limits include ...

    Application of Novel Nanoscale Materials and Advanced Electrochemical Techniques in Heterogeneous Catalysis and Fabrication of Combinatorial Material Libraries by Bipolar Electrodeposition 

    Ramakrishnan, Sridevi (2011-09-08)
    The advancements in the electrochemical technologies combined with the introduction of novel materials makes our lives a lot better. This work has two major divisions: (1) development of better electrocatalysts for fuel ...

    Applications of Polyoxometalates as Electron Mediators 

    Gu, Chaokang (2009-10-15)
    The large variety of size, structure and elemental composition of polyoxometalates leads to a wide range of different properties. The primary goal of this dissertation is to study the structure-property relationship of ...

    An Approach to Bis(amino Acid)s Utilizing Dimethyl 2,4-bis(diazo)-3-oxoglutarate and Studies of Tris(2,6-dihydroxyphenyl)e, E = B, P. 

    Guan, Lirui (2008-09-09)
    When treated with a diazo transfer agent, dimethyl 3-oxoglutarate afforded a high yield of the bis(diazo) compound dimethyl 2,4-bis(diazo)-3-oxoglutarate, 33. The bis(diazo) compound, catalyzed by Rh2(OAc)4, reacted with ...

    Biophysical characterization of ligand binding and release of Anthereae polyphemus Pheromone Binding Protein 1 (ApolPBP1) and Exploring the nickel proteome 

    Mazumder, Suman (2013-08-07)
    In moths, pheromone binding proteins (PBPs) transport the hydrophobic pheromone molecules to the membrane-bound receptors across the aqueous sensillar lymph to trigger the neuronal response. We showed here that, recombinant ...

    Bipolar Electrochemistry: A Powerful Technique for Chemical Analysis and Property Screening 

    Ndzesse Sanghapi, Axline (2013-04-23)
    The phenomenon of bipolar electrochemistry was first exploited about three decades ago in the industrial sector to minimize power dissipation and to carry out electrochemical reactions in poorly conducting media. However, ...

    Bipolar Electrochemistry: Chemical Analysis Based on Electrochemiluminescence and Surface Enhanced Raman Spectroscopy 

    Fan, Sanjun (2015-07-24)
    Bipolar electrochemistry has a variety of applications ranging from chemical analysis, material modification and synthesis, to generate motions, etc, and it is also a very simple, cheap, useful technology. The main goal ...

    Carbocyclic C-Nucleosides Derived from Formycin 

    He, Mingzhu (2009-02-23)
    Analogs of naturally occurring nucleosides have served as structural models for the design of antitumor, antiviral, and antibacterial agents. Some modified nucleosides have become major therapeutic agents for the treatment ...

    Catalytic Mechanism of a Flavin-Dependent Alkanesulfonate Monoxygenase from Escherichia coli 

    Zhan, Xuanzhi (2008-09-09)
    The flavin-dependent alkanesulfonate monooxygenase (SsuD) catalyzes the oxidation of alkanesulfonate to aldehyde and sulfite in the presence of O2 and FMNH2 provided by an FMN reductase (SsuE). The goal of these studies ...

    Characterization of the iron center in cysteine dioxygenase and kinetic analyses of flavin binding by the alkanesulfonate flavin reductase 

    Sun, Honglei (2008-09-09)
    Cysteine dioxygenase (CDO) and the flavin reductase, SsuE, are both important proteins in sulfur metabolism. CDO catalyzes cysteine oxidation which is a key step in cysteine metabolism in mammalian systems. SsuE is a flavin ...

    Characterization of the mechanism of 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH) 

    Xiao, Xiao (2013-08-21)
    In this thesis, two projects were carried in the context of understanding the reaction mechanism of 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (also called HMBPP reductase or IspH). The first project is the ...

    Characterization of Two-component Organothiol Mixed Monolayers on Gold and Quantification of Nonspecific Adsorption on Mixed Sam Biosensor Platforms Using Electrochemical Enzyme Immunoassay 

    Liu, Huiqing (2008-09-09)
    Self-assembled monolayer (SAM) technology provides a simple and useful way to functionalize biosensors. The formation and characterization of SAM monolayers are briefly reviewed in Chapter One. Several selected examples ...

    Chemically Modified Electrodes: A Supramolecular Assembly Approach 

    Xin, Junhua (2009-02-23)
    The main objective of this dissertation is to design and study new superamolecular assemblies for membrane separation, sensing and catalysis applications. Three types of supramolecular assemblies will be addressed including ...

    Chemistry in silico: Organic Reactions, Ionic Liquids, Tautomerization 

    McCann, Billy (2013-04-22)
    Computational chemistry is a collection of methods that seek to interpret and predict chemical phenomena. In this work, three distinct areas of chemistry are investigated: (1) the reactive pathways of UVA irradiated ...

    Computational Investigation of Condensed Phase Properties of Ionic Systems 

    Lee, Tae Bum (2012-04-17)
    Four computational studies have been performed with various computational techniques including density functional theory, post-HF theory, and implicit solvation modeling to investigate the dehydrogenation mechanism of ...

    A Computational Mechanistic Study of an Aza-Michael Addition and a Paal-Knorr Reaction 

    Li, Bin (2015-01-13)
    Computational chemistry is a rapid growing branch of chemistry that seeks to interpret chemical problems and predict chemical phenomena using mathematical approximations and computer programs. In the present work, we ...

    Copper(II)-Mediated 2-Quinoxalinol Salens in Alcohol Oxidation and C-H Activation: A Greener Approach 

    Weerasiri, Weerasiri Arachchige Kushan (2014-07-11)
    Reduction of waste production in chemical processes is the idea of greener chemistry by using less toxic or benign methods and eliminating purification steps. Because of this, using a catalytic rather than stoichiometric ...