Browsing Auburn Theses and Dissertations by Department "Pathobiology"
Now showing items 1-18 of 18
Altered Expression Profiles and Defects in a Group of Cell Cycle Regulators and Tumor Suppressor Genes (INK4) and Evaluation of Comprehensive Expression Profiles of Canine miRNAs in Spontaneous Canine Breast Cancer Models
(2014-12-10)
The cyclin-dependent kinase inhibitors (CKIs) act as powerful cell cycle regulators and endogenous tumor suppressors. Defects in members of the INK4A/B CKI tumor suppressors have been associated with human and canine ...
Avian Infectious Bronchitis Coronavirus Variation and Selection
(2011-11-30)
Infectious bronchitis virus (IBV) is a highly variable virus, its genetic variation is
generated by nucleotide insertions, deletions, or point mutations made by the viral
polymerase during virus replication. Another ...
Avian Influenza Adenovirus-Vectored in Ovo Vaccination: Combination with Marek's Disease Vaccine
(2011-08-05)
Protective immunity against avian influenza (AI) can be elicited in chickens in a single-dose regimen by in ovo vaccination with a replication competent adenovirus (RCA)-free human adenovirus serotype 5 (Ad)-vector encoding ...
Cell-mediated immunity after ocular Ark-type infectious bronchitis virus vaccination
(2013-04-16)
Infectious bronchitis (IB) virus (IBV) is an endemic pathogen of poultry industry causing considerable economic losses by reducing quality and quantity of egg and meat production in chickens. In spite of intensive vaccination ...
Comprehensive analysis of the impact of endemic Chlamydia pecorum infection in cattle
(2012-11-16)
Intracellular Chlamydia (C.) bacteria cause in cattle some acute but rare diseases such as abortion, sporadic bovine encephalomyelitis, kerato-conjunctivitis, pneumonia, enteritis and polyarthritis. More frequent, essentially ...
The Cyclin-Dependent Kinase Inhibitor and Tumor Suppressor Locus p16/INK4A- p14ARF and Regulation of the Transition Into and Out of the Cell Cycle
(2011-12-06)
p16/INK4A/CDKN2A is an important tumor suppressor gene located in the INK4A/ARF locus, which encodes a 16 kDa protein known as p16, and a 14 kDa protein known as p14ARF in humans. p16 arrests cell cycle in early G1 phase ...
Development and Efficacy Assessment of Equine Source Hyper-Immune Plasma against Bacillus anthracis
(2015-07-29)
The objective of the studies described here was to develop an equine source immune plasma against Bacillus anthracis and test its efficacy in two in vitro applications; as well as determine its capacity for passive protection ...
Development and Screening of Targeted Anticancer Nanomedicines
(2015-07-29)
Cancer remains a significant healthcare burden worldwide and novel strategies to improve treatment outcomes with improved patient quality of life are needed. Recently, nanomedicines, which encapsulate a therapeutic drug ...
Development and Study of Phage-Derived Detection Probes
(2005-05-15)
The threat of bioterrorism has created a demand for continuous monitoring of the environment for threat agents. Existing monitoring systems use antibody-derived detection probes which are not hardy enough to withstand ...
Development Toward a Bovine Salmonella Model and a Bacteriophage Treatment Cocktail to Reduce Salmonella Peripheral Lymph Node Carriage in Calves
(2016-05-05)
Non-typhoidal salmonellosis is the leading bacterial cause of human foodborne disease in the United States and is responsible for numerous hospitalizations and deaths each year. Although several strategies have been ...
Gonadotropin-releasing Hormone Receptor As A Molecular Target for Contraception in Feral Cats
(2015-12-10)
The global overpopulation of feral cats generates concern regarding their welfare, negative impact on public health, and adverse effects on the environment. In the U.S. and other Westernized countries, the most common ...
Immunopathogenesis, prevention and control of Bovine viral diarrhea virus
(2012-07-17)
Bovine viral diarrhea virus (BVDV) is an important infectious agent that affects cattle worldwide (Baker, 1995; Houe, 1999). Acute infections with some strains of BVDV may cause immunosuppression and clinical signs of ...
Influence of Natural Chlamydia spp. Infection on the Health of the Ruminant Mammary Gland
(2010-01-22)
Exposure to obligate intracellular Chlamydia abortus and C. pecorum bacteria is ubiquitous in ruminants worldwide, with high seroprevalence rates approaching 100% in some investigations. This study aimed to analyze the ...
Landscape Phage-Targeted Drug Delivery to Breast Cancer Cells
(2010-12-08)
The prevalence of breast cancer is still a public health burden worldwide. Recently, there has been significant progress in the management of breast cancer with the two FDA-approved cancer nanomedicines employing the concept ...
Multivariate Analyses of Disease Outcomes of Chlamydial Infections in Cattle and Mice
(2005-05-15)
In humans, Chlamydia pneumoniae infection is implicated in 10 ~ 15% of bronchitis and community-acquired pneumonia, and 50 ~ 70% of adults have antibodies to Chlamydia pneumoniae. In livestock animals, ubiquitous C. abortus ...
Selection of Promiscuous Anti-Cancer Phage Proteins for Tumor Targeted Nanomedicines
(2015-07-28)
Cancer remains one of the leading causes of death and requires novel approaches in both management and treatment. Tumor targeting ligands have been identified to a variety of human cancer cell lines using phage display ...
Significance of viral subpopulations within Ark Serotype Infectious Bronchitis Vaccines
(2011-12-05)
As a result of spontaneous mutations and/or recombination occurring within the
viral genome, infectious bronchitis virus (IBV) exists as multiple serotypes and
genotypes that poorly cross protect. Molecular analysis of ...
Therapeutic Liposomes for Prostate Cancer Targeted by Phage Fusion Coat Proteins
(2009-12-15)
Cancer diagnosis and treatment is complicated by the molecular similarity of the malignant cells to normal cells. This creates a constant need for the development of probes accurately distinguishing between diseased and ...