Browsing Auburn Theses and Dissertations by Department "Biomedical Sciences"
Now showing items 21-40 of 70
Enhancement, Modulation and Electrophysiological Characterization of Murine Olfactory Neurons to Odorant Stimulation in Vitro
(2006-05-15)
The objectives of this study is to electrophysiologically characterize cultured
olfactory epithelium (OE) and to compare with that of rapidly isolated OE; to establish
the Gai involvement in the modulation of adenylyl ...
Evaluation of a novel antiviral compound effective against multiple pestivirus species
(2013-04-23)
Bovine viral diarrhea virus (BVDV) is a viral pathogen of cattle and other wild and domestic ungulates that is capable of affecting multiple body systems, most notably the gastrointestinal, reproductive, immune and respiratory ...
Evaluation of Transmission of Bovine Viral Diarrhea Virus (BVDV) Between Persistently Infected and Naïve Cattle by the Horn Fly (Haematobia irritans)
(2011-08-09)
Identifying transmission routes and reservoirs for bovine viral diarrhea virus (BVDV) are important in developing adequate prevention and control programs. The aim of our study was to evaluate BVDV transmission by the ...
Exploration Into the Effects of Hypoxia in an In Vitro Canine Glioblastoma Model
(2013-04-23)
Glioblastomas are aggressive, lethal primary brain tumors that affect human and canine patients. A subpopulation representing a variably large percentage of the bulk of tumor cells has been identified to have stem cell-like ...
Fluoroquinolone-associated mutations in soxS, a transcriptional regulator of AcrAB efflux pump
(2013-11-08)
Escherichia coli is a major cause of urinary tract infections in companion animals and efflux pump over expression has been associated with high-level fluoroquinolone (FQ) resistance. The purpose of this study was to ...
Functional Analysis of PRAF1 and Its Effect on Corticotrophic ACTH Secretion
(2007-08-15)
Prenylated Rab acceptor domain family member 1 (PRAF1), a transmembrane Golgi apparatus protein, interacts with Dexras1, a corticotrophic protein that may play a role in glucocorticoid-mediated inhibition of ACTH secretion. ...
Functional characterization and pharmacological rescue of the human and porcine neural melanocortin receptors
(2008-08-15)
During the past decade, numerous studies showed that both melanocortin-3 and -4 receptors (MC3R and MC4R) are critically involved in regulation of mammalian energy balance. The MC4R plays a vital role in regulation of food ...
Functional characterization of novel naturally occurring mutations in human melanocortin-3 receptor gene
(2012-12-03)
The prevalence of obesity is increasing in both developed and developing countries. Obesity is a disorder of energy homeostasis, associated with increased risk of diabetes mellitus, cardiovascular diseases and certain types ...
Gene Therapy Approaches for Neurological Lysosomal Storage Diseases
(2014-04-25)
GM1 and GM2 gangliosidosis are lysosomal storage diseases caused by deficiency of enzymes required for ganglioside catabolism. Enzyme deficiencies cause neuronal accumulation of ganglioside resulting in progressive ...
Heat stress and ischemia/reperfusion cause oxidative stress via NADPH oxidase in hypothalamic neurons
(2009-04-29)
Ischemia/reperfusion-related injuries are associated with a wide range of diverse disorders including but not limited to aging, heat stroke, diabetes and Alzheimer’s disease. Ischemia/reperfusion is known to cause oxidative ...
Heat Stress Induces Downregulation of Hippocampal Superoxide Dismutase-1; a Possible Mechanism for Heat-Related Neuronal Cell Death
(2006-12-15)
Exertional heat injury represents a major risk for people working or exercising in hot environments. Currently, no pharmacological therapies are available and little is known about the molecular response to heat stress in ...
Immunohistochemical Localization of the Melanocortin-4 Receptor (MC4R) in the Colon Myenteric Plexus
(2010-08-04)
Alpha-melanocyte stimulating hormone (α-MSH) is a tricdecaneuropeptide that can bind four melanocortin receptors (MC1R, MC3R-MC5R) to exert various receptor-dependent effects. MC4R regulates several functions which include ...
Immunomodulatory Effects of Intracranial Gene Therapy in Feline Sandhoff Disease
(2014-05-02)
Sandhoff disease (SD) is a lysosomal storage disorder characterized by absence of hydrolytic enzyme β-N-acetylhexosaminidase (Hex), which results in storage of GM2 ganglioside in neurons and unremitting neurodegeneration. ...
Impact of Antimicrobial Therapy on Fecal Escherichia coli in Dogs
(2009-05-05)
Antimicrobial resistance is an emerging aspect of antimicrobial therapy. However, few studies have documented this relationship in vivo. The purpose of this study was to describe the relationship between antimicrobial ...
In Ovo-Vaccination with a Non-Replicating Adenovirus-Vectored Avian Influenza: Maternal Immunity and Effects on Vaccination
(2011-11-17)
Protective immunity to avian influenza (AI) virus can be elicited in chickens by in ovo or intramuscular (IM) vaccination with RCA-free adenovirus vector encoding AI virus H5 (AdH5). We evaluated persistence of specific ...
In silico Prediction and Experimental Confirmation of B-cell Epitopes for Molecular Serology of Chlamydia spp.
(2016-03-25)
Urgently needed species-specific ELISAs for detection of antibodies against Chlamydia (C.) spp. have been elusive due to high cross-reactivity of chlamydial antigens. To identify Chlamydia species-specific B-cell epitopes, ...
In Vitro Determination of Canine Immunological Responses Due to Exposure to Recombinant Wolbachia Surface Protein
(2011-07-21)
Dirofilaria immitis is the causative agent of heartworm disease in several hosts, including dogs and cats. Like other filarial parasites, D. immitis harbors a strain of Wolbachia pipientis, an obligate, intracellular, ...
In vivo Endothelial Cell Infection by Anaplasma marginale
(2007-05-15)
Anaplasmosis is an arthropod-borne hemoparasitic disease of cattle and other ruminants. The causative agent is the gram negative bacterium, Anaplasma marginale. Infection of bovine erythrocytes by A. marginale has been ...
Influence of the Chicken Major Histocompatibility Complex on the Pathogenesis of Bacterial Skeletal Disease, Chicken Infectious Anemia and Infectious Bronchitis
(2006-12-15)
Genetic resistance to several poultry pathogens has been unequivocally linked to the major histocompatibility B complex (MHC). Relatively few MHC association studies have been conducted during natural disease outbreaks, ...
Interferon Kinetics and its effect on DNA vaccine induced immunity in channel catfish (Ictalurus punctatus)
(2008-08-15)
Increasing the effectiveness of vaccination against channel catfish diseases, including channel catfish virus (CCV) is important economically and clinically for channel catfish farming. Catfish interferon (IFN), an innate, ...