Browsing Auburn Theses and Dissertations by Department "Interdepartmental Pharmacy"
Now showing items 21-40 of 63
Establishment and optimization of the LC-MS-based strategy for screening of passively absorbed açaí and maca constituents for CYP3A4 inhibition
(2017-07-27)
The escalation of cancer morbidity and mortality has increased the use of botanical dietary supplements among cancer patients undergoing chemotherapy. Euterpe oleracea Mart. (açaí) berry and Lepidium meyenii Walpers (maca) ...
Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling
(2020-05-14)
In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...
Examining the Effects of Text Message and Competition-Based Interventions on Physical Activity, Self-Efficacy, Self-Regulation, Social Support, Incentive Motivation, and Mental Well-being among University Students
(2023-08-02)
Background: Compelling evidence highlights the importance of physical activity and its numerous benefits for both physical and mental well-being. However, physical activity levels remain low, particularly among university ...
Formulation of Water Insoluble Drugs for Ocular Delivery
(2018-07-24)
Cyclodextrins are unique cyclic molecules with a hydrophobic interior and hydrophilic exterior that can be used to solubilize, stabilize and enhance targetability of the encapsulated molecules. Chapter 1 will discuss uses ...
Geographical Access, Implementation Experience, and Patient Perception of Genetic Testing in the United States
(2022-06-29)
Backgrounds: Genetic testing is thriving, and its impact on human lives is enormous. However, the slow uptake of genetic testing into routine clinical practice indicates that much remains to be explored with regards to ...
Illuminating the Neurotoxic Effects of TFMPP derivatives in N27 Rat Dopaminergic Neuronal Cells through Oxidative Stress and Mitochondrial Dysfunction
(2017-05-03)
The use of designer drugs in the United States have increased tremendously. Designer drugs
are highly dangerous and most importantly the abusers don't have a clue with regard to what they
are getting. Thus, it is currently ...
Immunoproteasome Inhibitors for the Treatment of MLL-AF4 ALL
(2024-02-15)
Acute lymphoblastic leukemia, ALL, is a cancer of the blood or bone marrow that develops from the uncontrolled proliferation of lymphocytes. One subtype of ALL is caused by a translocation involving the MLL gene, or mixed ...
Impact of the COVID-19 Pandemic on Pharmacy-based Immunization in Rural USA: a cross-sectional study of community pharmacists from five Southeastern States
(2021-11-29)
Background: Immunization rates for seasonal and non-seasonal vaccines dropped during the COVID-19 pandemic. Little is known about the extent to which community pharmacies continue to serve as immunization sites during the ...
Impact of Tumor Microenvironment on Intratumor Distribution of Liposomes in Prostate Cancer
(2022-07-25)
Extensive developments in nanocarrier formulations and their applications in cancer therapy have occurred in the last few decades. This improvement brought many FDA-approved liposome nanoparticles (LNPs) and other nanoparticle ...
Incorporating Patient Input into Value-based Community Fall Prevention for Older Adults: Evaluating Patient Preferences and Willingness to Pay
(2019-07-23)
Background:
Falls are the leading cause of injury-related death and non-fatal injuries in US older adults, including hip fracture and traumatic brain injury. Current evidence-based fall prevention programs exist in ...
Integrating single-cell multi-omics and experimental therapeutics to identify and validate novel secondary therapies against relapsed/refractory cancers
(2023-02-27)
Drug resistance has remained the Achilles' heel in cancer chemotherapy which serves as the principal limiting factor in achieving favorable treatment outcomes in cancer patients. Drug resistance that exists even before ...
Investigate the dopaminergic neurotoxicity profile of designer drugs (Piperazine derivatives)
(2018-05-14)
Different botanical derived, or synthetic addictive substances have been “misused” and/or “abused” for centuries around the world. To overcome the abuse by these substances, strict legal laws were constituted globally. ...
Investigating the Role of Aging and Pathological Tau in Alzheimer's Disease
(2021-12-06)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by
accumulation of plaques made of insoluble beta-amyloid protein, neurofibrillary tangles
containing hyperphosphorylated tau protein, ...
Is the Continuity of Care for Comorbidities among Breast Cancer Patients Related to Treatment Adherence and Survival Outcomes?
(2019-07-23)
Background: Breast cancer patients with comorbidities need to see multiple healthcare providers. These patients often need to take multiple medications, have frequent health care service utilization and high costs, and ...
Leveraging Behavioral Economics-based Interventions to Improve Medication Adherence
(2017-08-18)
Poor medication adherence to chronic medications can lead to added patient harm and increased costs. Concepts from behavioral economics have guided interventions to help overcome the tendency toward non-adherence with ...
Lysophosphatidic Acid Induces Tau Hyperphosphorylation by Dysregulation of Kinase and Phosphatases
(2022-12-08)
The increased incidence of Alzheimer’s disease (AD) indicates an unmet medical need to develop novel molecular targets for therapeutic potential. Alzheimer’s disease is primarily classified into early-onset (genetic) and ...
Molecular modeling, design, and synthesis of some potential selective DNA minor groove alkylators
(2021-12-03)
Small molecules-DNA interactions are responsible for many biological processes. The DNA present in normal and tumor cells are almost identical. Therefore, DNA targeting drugs are used only in serious and life-threatening ...
Motivational Interviewing for Diabetes Medication Adherence in Type 1 Diabetes and Type 2 Diabetes Patients
(2018-07-24)
Objectives: Medication adherence is vital towards achieving adequate glycemic control in diabetes management. Workplace Wellness Programs (WWPs) for chronic disease management offer a unique setting for employers to offer ...
Myocardial Ischemia/Reperfusion Injury and Cardioprotection: Novel Roles of Frataxin and Uridine Triphosphate
(2017-04-21)
Ischemia reperfusion (IR) injury in cardiac myocytes is well known to provoke membrane damage that is mediated by oxygen free radicals and that is associated with iron accumulation, energy dysregulation and opening of the ...
Nanoparticles-based Drug Delivery Systems for Resistant Cancer Treatment
(2021-11-29)
Many FDA-approved drugs have been repurposed as anticancer agents to fulfill the increasing demand for more effective anti-cancer drugs especially for drug-resistant cancers. Disulfiram (DSF) is an FDA-approved drug which ...