Browsing Auburn Theses and Dissertations by Department "Pharmacy"
Now showing items 21-29 of 29
Regulation of SLC19A3 thiamin transporter by HIF-1α
(2016-08-04)
Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that regulates gene expression in response to hypoxia, including SLC19A3, thiamine transporter 2, a facilitative carrier that mediates intracellular uptake ...
Role of CXCR7 in Human Coronary Artery Smooth Muscle Restenosis
(2019-07-12)
Objective—Whether CXCR7 is a signaling or non-signaling scavenger receptor is still in debate. Our previous study showed that during monocyte-to-macrophage differentiation, CXCR7 mediates positive signaling to the p38 and ...
The Role of Frataxin in Doxorubicin Mediated Cardiac Hypertrophy
(2016-07-29)
Doxorubicin (DOX) is a highly effective anti-neoplastic agent, used to treat a wide range of cancer. However, the clinical application of DOX is limited due to its dose dependent cardiotoxic complications which eventually ...
Role of P2Y2 Receptor in Metformin-Improved Insulin Resistance in Skeletal Muscle Cells
(2019-07-11)
Abstract
Objective—It has been shown that high extracellular glucose promotes ATP release in different cells, but its biological significance is not clear. Also, it has been reported that extracellular ATP either increase ...
Short-Chain Ceramides for Enhancing Cytotoxicity of Liposome-Encapsulated Doxorubicin Toward Human Breast Cancer (MDA-MB-231) and Prostate Cancer (PC-3) Cells
(2016-08-01)
Co-delivery of short chain ceramide, C6-Ceramide (C6-Cer) and C8-Ceramide (C8-Cer) and doxorubicin (DOX) using a liposomal system in MDA-MB-231 breast cancer and PC3 prostate cancer cell lines for synergistic cytotoxic ...
Synthesis, Analytical Profiles and Receptor Pharmacology of Methoxylated Derivatives and Regioisomers of the NBOMe series of Hallucinogenic Drugs
(2019-04-23)
The potential for designer analogue development in the NBOMe series of drugs of abuse
is very high based on the methods used to synthesize this class of compounds, and the availability
of a wide variety of precursor ...
Synthesis, GC–MS, GC–MS/MS, GC–IR and chromatographic studies on cathinone derivatives related to methylenedioxypyrovalerone (MDPV)
(2018-12-03)
This project will address issues of resolution and discriminatory capabilities for cathinone derivatives (regioisomeric and homologous groups) providing additional reliability and selectivity for forensic evidence and ...
Targeting Neuroinflammation as a Therapeutic Approach in Alzheimer’s Disease Mouse Model
(2020-08-24)
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common form of dementia that affects people in their middle age, in the case of familial cases, and the elderly causing significant losses to ...
Toxicity Screening of Novel Myeloperoxidase Inhibitors Using Zebrafish Model
(2018-06-26)
Myeloperoxidase (MPO) is a heme-containing enzyme, which is stored and released by neutrophils and monocytes. MPO catalyzes the production of hypochlorous acid from hydrogen peroxide and chloride ion. Hypochlorous acid ...