Browsing Auburn Theses and Dissertations by Department "Chemistry and Biochemistry"
Now showing items 41-60 of 245
Design and Synthesis of AdoHcy Hydrolase Inhibitors as a Source of Antiviral Agents
(2008-05-15)
The significant antiviral properties of the carbocyclic nucleosides aristeromycin and neplanocin A have been attributed to inhibition of AdoHcy hydrolase, which in turn affects viral mRNA capping methylation. However, their ...
The Design, Synthesis and Application of Redox-Responsive MRI Contrast Agents
(2015-07-29)
Reactive oxygen species (ROSs), such as hydroxyl radicals, superoxide anions and hydrogen peroxide, are side products of aerobic respiration. Although ROSs regulate several physiological processes, they have been implicated ...
Development and Application of New Platforms for Oligonucleotide and Protein Assays
(2020-07-20)
Sensitive and rapid detection of infectious disease is becoming very significant to improve human health. We have seen that the sensitive methods often required expensive, and sophisticated instruments. Biosensors are ...
Development and Applications of New Platforms for Electrochemical Sensors
(2012-07-27)
The primary goal of this dissertation is to develop electrochemical sensors based on novel platforms for applications in medical diagnostics, food safety, and environmental management. Attempts have been made to integrate ...
Development and Synthesis of Mononuclear Superoxide Dismutase Mimics and Magnetic Resonance Imaging Contrast Agents
(2021-04-26)
Over the past few years the Goldsmith group has reported mononuclear superoxide
dismutase mimics and Mn(II) complexes with redox-active quinols that display rapid T1-
weighted responses to H2O2. This dissertation will ...
The Development of a Nucleic Acid-Directed Switch and Proximity Dependent Protein Assays using Electrochemical Techniques
(2018-10-09)
The analysis of nucleic acids (NA), has increased demand for point-of-care systems, such as rapid preventive health care, forensic applications, etc. Thus inspired, a vast amount of biosensor platforms for the detection ...
Development of automated microfluidic devices for quantifying nutrient uptake and release from murine adipose tissue with fluorescence imaging
(2023-12-05)
This study aims to advance the knowledge of diabetes-associated biological assays such as white adipose tissue secreted glycerol and fatty acid uptake and secretion assays by leveraging the incorporation of microfluidic ...
THE DEVELOPMENT OF BIFUNCTIONAL ALLYLBORONATE REAGENTS FOR STEREOSELECTIVE CARBONYL ALLYLBORATION
(2023-07-17)
CHAPTER 1
The synthesis of a bifunctional allylboron reagent via Ni-catalyzed borylation of allylic acetate is developed. Subsequent allylation of aldehydes, ketones and cyclic aldimines gave homoallylic alcohols and ...
The Development of Bipolar Electrochemiluminescence Sensing Systems using Thin-layer Electrochemistry and AC Excitation
(2018-12-10)
Bipolar electrochemistry, which generates an asymmetric reactivity on the surface of conductive objects in a wireless manner, has become a promising field for various applications. It enables the coupling of anodic and ...
Development of Nucleic Acid Driven Peptide and Protein Sensors and Their Integration with Automated Microfluidics
(2020-08-14)
Accurate detection of disease-associated biomolecules is one of the most critical steps in diagnostics in the early stages of disease to provide appropriate health care and effective treatment to patients. In clinical ...
Development of Oligonucleotide, Small Molecule, and Protein Assays using Square-wave Voltammetry with Electrode-bound Nucleic Acid Nanostructures
(2018-01-09)
Biomarker analysis plays a decisive role in health care. This role is not only limited to disease diagnosis, but it also involves understanding of biological and physiological functions in order to monitor health, observe ...
The Development of Pi-Extension Strategies for the Conversion of Strained Benzenoid Macrocycles to Curved, PAH Segments of Carbon Nanotubes
(2021-12-06)
Chapter 1: The synthesis of smallest carbon nanoring, [4]CPP and its potential precursor
has been an area of interest for last decade. The challenge associated with synthesis of
this highly strained nanoring is ...
Development of Plug-and-Play 3D-Printed Micropneumatic Circuit Modules for Autonomous Control of Fluidic Devices
(2025-08-04)
This dissertation presents an exploration of the design, fabrication, and characterization of integrated pneumatic circuits for the precise control of microvalves within droplet-based microfluidic devices. By integrating ...
Development of Raman and Electrochemical Biosensors and Fabrication of Hybrid Materials for Supercapacitors
(2013-06-14)
This dissertation describes the development of sensors for the detection of biologically relevant molecules and the fabrication of hybrid supercapacitor materials for energy storage purposes. Specifically, DNA sensors based ...
Development of real-time, quantitative free fatty acid uptake assays for adipose tissue explants using fluorescence and microfluidics
(2017-04-25)
Free fatty acid (FFA) uptake by adipocytes in response to nutritional or hormonal stimuli is a key process in the complex metabolic cascade leading to diabetes and obesity. The work presented in this thesis is focused on ...
Development of thermally regulated homogeneous assays and droplet-based microfluidic tools for probing secretion dynamics from pancreatic and adipose tissues
(2018-07-24)
Cells can transmit signals and adapt to microenvironment variations rapidly with dynamic
processes, such as biomolecule secretion for signal delivery. Dynamic, oscillatory secretion is
expected to exist in many cell ...
Diastereoselective Transformations of Macrocyclic 1,4-Diketones for the Synthesis of Cyclobutane-containing Natural Products
(2020-12-01)
Macrocyclic conformation has been investigated since the 1950s. The understanding of this phenomenon has been applied to predict and explain diastereoselective reactions to macrocyclic systems since this time, and correlation ...
Dioxygen reduction and Superoxide dismutase mimicry using first row transition metal complexes with redox active organic ligands.
(2024-04-22)
The efficient activation of small molecules, such as dioxygen (O2) and superoxide (O2-), is key to solving several energy- and health-related challenges. The selective reduction of O2 to water (H2O) is integral to the ...
DNA-based Proximity Assays for Biomarker Detection Using Fluorescence and Electrochemistry with Improved Performance through Probe Flexibility
(2023-04-27)
Detection of biomarkers is important in understanding the mechanisms underlying a disease and developing therapeutics for treatment and cure. Although there are several sensitive and specific analytical techniques revolving ...
Doctoral Education in Chemistry: 21st-Century Challenges and Prospects for Reforms
(2025-07-30)
Doctoral education in chemistry (DEC) plays a pivotal role in advancing scientific knowledge, training independent researchers, and preparing graduates for diverse career paths. This dissertation examines the goals, ...