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Determination of Safe and Effective Dosing Regimens for Nonsteroidal Anti-inflammatory Drugs in African and Asian Elephants.
(2019-07-29)
Arthritis and foot disease are well documented conditions affecting captive elephants that are frequently treated with nonsteroidal anti-inflammatory drugs (NSAIDs). An important consideration regarding efficacy and safety ...
Clinical Applications of Therapeutic Drug Monitoring in Canine Idiopathic Epilepsy Patients Receiving Levetiracetam
(2018-11-20)
There are currently no drugs approved for the treatment of canine idiopathic epilepsy and as a result extra-label use of human-approved medications is common. Older agents such as phenobarbital are effective in dogs, but ...
In vitro anti-tubulin effects of mebendazole and fenbendazole on J3T canine glioma cells
(2016-08-24)
Benzimidazole anthelmintics have reported anti-neoplastic effects both in vitro and in vivo. The purpose of this study was to evaluate the in vitro chemosensitivity of canine glioma J3T cells to mebendazole and ...
Detection of Tritrichomonas foetus in Bovine Semen by PCR Amplification
(2016-12-09)
Bovine trichomoniasis caused by Tritrichomonas foetus, is a true venereal disease of cattle that is spread only through coitus. The objective of the study was to determine if a T. foetus infection could be detected in ...
Neuroprotective effects of carnitinoid antioxidants in rodent models of mitochondrial dysfunction
(2016-07-27)
The pathological effects of mitochondrial dysfunction result from both oxidative damage and bioenergetic deficiency, and are more severe in cells and tissues with high metabolic energy demands such as neurons, skeletal ...
Use of Accelerometers to Characterize Behavior in Beef Cattle During Health and Subclinical Disease
(2017-11-30)
The acute phase response (APR) represents a protective, coordinated response of the host with the aim of eliminating the inciting stimuli and re-establishing homeostasis. Produced by activated immune cells, proinflammatory ...
Effect of Omega 3, 6 and 9 Fatty Acids and Vitamin E on Canine Semen Concentration, Motility, Morphology and Cryopreservation
(2018-07-20)
There are few studies in dogs investigating the efficacy of male fertility supplements, most notably fatty acids. The objective of this study was to investigate the effects of a commercial fatty acid supplement (OM3 Gold ...
Orally administered torsemide in horses: pharmacokinetic and pharmacodynamic studies
(2018-08-02)
Diuretic therapy is the mainstay for management of congestive heart failure in horses. Loop-diuretic medications in horses have been restricted to injectable medications because currently, no data support the use of ...
Pharmacodynamic Effects of Pioglitazone on High Molecular Weight Adiponectin Concentrations and Insulin Response after Oral Sugar in Equids
(2019-07-10)
Chronic insulin dysregulation is challenging to manage with pharmaceuticals in horses. Pioglitazone improves insulin sensitivity in humans, and the pharmacokinetics of pioglitazone have been evaluated in horses. The ...
Methods for Isolating Canine Mast Cell Progenitors, Melanocytes, and Keratinocytes
(2020-04-21)
One of the most difficult aspects of employing precision medicine in the treatment of cancer is determining the best targets to treat within the tumor. A trademark of cancers is that, while two patients may present similar ...