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Exploring sinefungin analogs as potential antiviral agents
(2008-09-09)
Sinefungin bears a strong structural resemblance to S-adenosylmethionine and S-adenosylhomocysteine and, therefore is one of the most potent inhibitors of viral mRNA methyl transferase. Besides antiviral activity, sinefungin ...
Exploring Potential Energy Surfaces and Reaction Mechanisms of Inorganic Molecules by Computational Methods
(2008-09-09)
Various computational methods have been applied in order to explore potential energy surfaces (PES) and reaction mechanisms. Theoretical background and computational methods are introduced in chapter 1. Chapters 2-5 ...
Hydrothermal Synthesis and Characterization of Novel Thorium, Uranium, and Neptunium Solids
(2008-09-09)
Hydrothermal synthesis has been utilized to synthesize several compounds involving thorium, uranium, and neptunium. These compounds have one-, two-, and three-dimensional structural typologies. A majority of the compounds ...
Self-Assembled Monolayers as Platform for Biosensors
(2008-09-09)
In chapter one, self-assembled monolayers (SAMs), the platform for biosensors,
were discussed in detail regarding surface pKa, stability, and chemical reactions. Mixed
self-assembled monolayers, especially when incorporated ...
Electrochemical/Electrospray-Mass Spectrometric Studies of the Oxidation of Iodide and Cyanide at Gold and Platinum Electrodes as well as Gas Phase Multiply-Charged Fullerene C60 Anions.
(2008-09-09)
In this dissertation, we introduce a new spherical thin-layer flow cell to interface
electrochemistry with electrospray mass spectrometry. The successful applications of
the electrochemistry with electrospray mass ...
An Approach to Bis(amino Acid)s Utilizing Dimethyl 2,4-bis(diazo)-3-oxoglutarate and Studies of Tris(2,6-dihydroxyphenyl)e, E = B, P.
(2008-09-09)
When treated with a diazo transfer agent, dimethyl 3-oxoglutarate afforded a high yield of the bis(diazo) compound dimethyl 2,4-bis(diazo)-3-oxoglutarate, 33. The bis(diazo) compound, catalyzed by Rh2(OAc)4, reacted with ...
Roles of Two Interhelical Insertions in Catalase-peroxidase Catalysis: Tracing the Impact of Peripheral Protein Structures on Heme Enzyme Function
(2008-09-09)
Monofunctional peroxidases and bifunctional catalase-peroxidases share almost superimposable active sites, yet peroxidases lack appreciable catalase activity. Moreover, catalase-peroxidases catalyze both catalase and ...