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Roles of Large Loops in Catalytic Versatility of Catalase-Peroxidases: Significance of Peripheral Structures in Improvising Enzyme Functions
(2012-05-07)
Catalase-peroxidases are bifunctional enzymes that catalyze the removal of hydrogen peroxide by two distinct pathways (catalase and peroxidase). They are central to antibiotic resistance in Mycobacterium tuberculosis and ...
Structural and Functional Studies to Investigate Enzymatic Catalysis and Flavin Transfer Mechanism of The Two-component Alkanesulfonate Monooxygenase System from Escherichia coli
(2012-05-07)
Several bacterial organisms rely on the two-component alkanesulfonate monooxygenase system for the acquisition of organosulfonate compounds when inorganic sulfur is limiting in the environment. This system is comprised of ...
2-Quinoxalinol Based Schiff Base Ligands in Copper(II)-Mediated C-H Activation
(2012-08-01)
As environment and energy issues become of increasing concern, so too does our awareness of the impacts of chemical industry. Numerous successful attempts toward “green” or “greener” chemistry have been made. Among these, ...
The Identification of Critical Active-Site Groups and Catalytic Steps Governing the Desulfonation Reaction by Alkanesulfonate Monooxygenase
(2012-10-08)
The alkanesulfonate monooxygenase enzyme (SsuD) catalyzes the oxygenolytic cleavage of a carbon-sulfur bond of sulfonated substrates. A mechanism involving acid-base catalysis is proposed for the desulfonation mechanism ...
A Novel Halogenation Protocol and Non-heme Iron Hydroxylase Mimics as Catalysts for C-H Oxidation and O2 Activation
(2012-08-03)
Hydrocarbons react with molar concentrations of peracetic acid and halide salts to yield predominantly monohalogenated products under optimum conditions, with chlorination being more oxidatively efficient than bromination. ...
Regioselectivity of the Photoisomerization of Acyclic 1,3-Dienes and Stable Trans Cycloheptenes
(2012-12-05)
There is still no complete understanding of how the visual system controls the
regioselectivity of the photoisomerization of the C11=C12 double bond in the visual
chromophore retinal. In this work we used a series of ...
Gene Duplication and Fusion: Strategy for Active Site Control and Starting Point for New Catalysts
(2012-12-10)
Catalase–peroxidases (KatGs) have two peroxidase-like domains. The N-terminal domain contains the heme-dependent, bifunctional active site. Though the C-terminal domain lacks the ability to bind heme or directly catalyze ...
Computational Investigation of Condensed Phase Properties of Ionic Systems
(2012-04-17)
Four computational studies have been performed with various computational techniques including density functional theory, post-HF theory, and implicit solvation modeling to investigate the dehydrogenation mechanism of ...
Molecular Photovoltaic Systems Based on Phospholipids/Alkanethiol Hybrid Bilayer Membranes: Photocurrent Generation and Modulation
(2012-07-23)
Biological membranes offer an ideal place to assemble necessary components for plant
photosynthesis in nature and suggest new strategies to build artificial photosynthetic systems by
using lipid bilayers. In this ...
Platinum nanoparticle-polyoxometalate based bimetallic catalyst for proton exchange membrane fuel cell and bipolar electrodeposition based combinatorial material library applied in sensors and energy systems
(2012-05-01)
The first part of chapter 1 summarizes the reports on the improved oxygen reduction reaction (ORR) kinetics on Pt-bimetallic catalysts used in proton exchange membrane fuel cell (PEMFC). An account on the significance of ...