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Lock-In Detection with Microfluidic Droplets for Quantitative Bioanalysis in Sub-Nanoliter Volumes
(2013-11-15)
The following chapters introduce and describe novel droplet microfluidic techniques to assist with limits of detection of analytes with low signal-to-noise ratios. The approach is proven feasible with absorbance measurements ...
Structure, dynamics and interaction study of Glutaminase Interacting Protein (GIP) and its complex with Glutaminase L and Brain-specific Angiogenesis Inhibitor 2 (BAI2) peptide and characterization of subunit A of Heterodisulfide Reductase (HdrA) from Methanothermobacter marburgensis
(2013-07-30)
Glutaminase interacting protein (GIP) is a 124 amino acid long protein containing a single PDZ domain. This protein intersects a number of important biological pathways. In many of these pathways, the mechanism of function ...
Biophysical characterization of ligand binding and release of Anthereae polyphemus Pheromone Binding Protein 1 (ApolPBP1) and Exploring the nickel proteome
(2013-08-07)
In moths, pheromone binding proteins (PBPs) transport the hydrophobic pheromone molecules to the membrane-bound receptors across the aqueous sensillar lymph to trigger the neuronal response. We showed here that, recombinant ...
Chemistry in silico: Organic Reactions, Ionic Liquids, Tautomerization
(2013-04-22)
Computational chemistry is a collection of methods that seek to interpret and predict chemical phenomena. In this work, three distinct areas of chemistry are investigated: (1) the reactive pathways of UVA irradiated ...
Plasma Propellant Interactions: RDX Films in Hydrogen, Argon, and Mixed Composition Plasmas
(2013-04-29)
The interaction of the components in electrothermal chemical (ETC) ignition have been studied due to its advantages over conventional ignition. In ETC ignition, a piece of polyethylene replaces the primer found in conventional ...
QM/MM/MC Simulations for the Elucidation of Ionic Liquid Solvent Effects upon Organic Reactions
(2013-04-30)
The research in this dissertation is focused on elucidating and understanding ionic liquid solvent effects on classical organic reactions. Ionic liquids are an exciting class of solvents that have attracted the attention ...
Transition Metal Manganese and Main Group Gallium Complexes as Catalysts for Alkene Epoxidation
(2013-04-29)
Epoxides are important organic synthesis precursors and widely used in industry. Alkene epoxidation has been under extensive investigation over decades. Synthetic models have been established for catalytic epoxidations, ...
Improved Proximity Assays for Protein Quantitation
(2013-06-05)
The work presented in this dissertation is focused on the development of proximity assay formats for biosensor applications in medical diagnostics, biological research, and point-of-care testing. An electrochemical proximity ...
Development of Raman and Electrochemical Biosensors and Fabrication of Hybrid Materials for Supercapacitors
(2013-06-14)
This dissertation describes the development of sensors for the detection of biologically relevant molecules and the fabrication of hybrid supercapacitor materials for energy storage purposes. Specifically, DNA sensors based ...
Synergy not Antagonism in Antioxidant Defenses: The Unanticipated Effect of Electron Donors on Catalase-peroxidase Function
(2013-04-22)
Catalase-peroxidases, also called KatGs, have raised considerable interest due to their role in the activation of isoniazid, an anti-tubercular pro-drug for Mycobacterium tuberculosis. KatGs are heme-dependent enzymes and ...