Search
Now showing items 1-10 of 10
The Efficiency of Enzymatic L-Cysteine Oxidation in Mammalian Systems Derives from the Optimal Organization of the Active Site of Cysteine Dioxygenase
(2014-04-22)
Intracellular concentrations of free cysteine in mammalian organisms are maintained within a healthy equilibrium by the mononuclear iron-dependent enzyme, cysteine dioxygenase (CDO). CDO catalyzes the oxidation of L-cysteine ...
Manganese and Iron Coordination Complexes for Biological Imaging and Oxidative Catalysis
(2014-04-23)
The ligand N,N’-bis(2-pyridylmethyl)-bis(ethylacetate)-1,2-ethanediamine (debpn)
coordinates divalent transition metal ions in either a pentadentate or hexadentate fashion. The coordination number correlates with the ionic ...
Investigations into 5ꞌ-Extended 3-Deazaaristeromycin Derivatives
(2014-05-02)
Nucleosides have provided a plentiful source in structural leads in antiviral drug discovery. Included in this class of compounds are the carbocyclic nucleosides, which because of the presence of a cyclopentyl moiety, offer ...
Copper(II)-Mediated 2-Quinoxalinol Salens in Alcohol Oxidation and C-H Activation: A Greener Approach
(2014-07-11)
Reduction of waste production in chemical processes is the idea of greener chemistry by using less toxic or benign methods and eliminating purification steps. Because of this, using a catalytic rather than stoichiometric ...
Polymeric System for Photochemical Generation of H2O2 and Initiator for Photoreduction of Hexavalent Chromium
(2014-12-04)
Stimuli responsive polymers (SRPs) have become a technological advancement in areas of materials, pharmaceuticals, and biomedical applications because the polymers can respond to small changes in the environment which can ...
Quinoxalinol based ligand for molecular recognition and selective extraction
(2014-04-29)
As the current age of nuclear reactors gets older, more waste and a greater
possibility of leaks can occur. There is a need for an on-site real time ability to be able to
detect actinides in the environment to prevent a ...
Formation and Passivation of Sub-Nanoliter Droplets for High Throughput Biological Assay Platforms
(2014-07-24)
In Vitro Compartmentalization (IVC) is a technique that utilizes water-in-oil emulsion droplets of fL – nL volume to compartmentalize and perform biological reactions and assays in parallel. At its highest capacity it has ...
Methyl-coenzyme M reductase: Elucidating the process of activation and study of the effect of the methanogenesis inhibitor 3-nitrooxypropanol
(2014-12-17)
To use methane as a biocatalyst, it is important to establish a cell free system to convert the inactive form of methane forming enzyme i.e Methyl-coenzyme M reductase (MCR) to the active form. MCR catalyzes the reversible ...
Synthesis and solid state characterization of actinide cyanometallates and actinide benzimidazole compounds
(2014-04-23)
The square-planar cyanometallate anions allow for the unique columnar structural feature
in the solid state, termed in the literature as pseudo 1-D M…M interactions in the Pt analogs. The
distance between metal sites has ...
KATG as a Defense Against Hydrogen Peroxide Toxicity: From a Redundant C-Terminal Domain to the Paradoxical Synergy of Two Mutually Antagonistic Activities
(2014-12-09)
Catalase-peroxidases (KatGs), first discovered in 1979, are heme-dependent enzymes mainly found in bacteria, archaea and fungi. They are capable of decomposing H2O2 by catalatic and peroxidatic pathways. KatG has garnered ...