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Microfluidic Interfacing for Primary Endocrine Tissue: Developing Bioanalytical Methodologies and Novel Fabrication Methods for Cell Culture and Analysis
(2016-12-09)
In order to bridge the gap between microfluidic designs and real world applications, microanalysis systems were developed using minimalistic design attributes which could be readily paired with compatible bioanalytical ...
Organic Molecule Functionalized Nanoparticles and Redox Active Polymer: Synthesis, Characterization and Application
(2016-12-12)
In the field of material chemistry, polymers and nanoparticles are most popular areas of current research and development. These two fields are quickly expanding and playing a vital role in a wide spectrum of areas ranging ...
Theoretical investigations of small molecule adsorption on pristine, doped, and perforated graphene
(2016-08-01)
Computational chemistry is a standard tool to understand chemical phenomena at the
electronic and molecular levels, and is a rapidly growing branch of chemistry. In this thesis,
three distinct computational chemistry ...
Iron-Sulfur Cluster-Containing Enzymes Involved in Isoprenoid Biosynthesis and Electron Bifurcation
(2016-05-05)
Iron-sulfur-cluster-containing proteins are present in all living organisms. They are involved in a wide array of biological processes such as electron transfer, substrate binding and activation, regulation of enzyme ...
Synthesis of Functionalized Benzenoid Macrocycles: An Approach to Accessing Functionalized Cycloparaphenylenes
(2016-05-02)
Carbon nanotubes (CNTs) are cylindrically shaped allotropes of carbon with exceptionally good electronic and optical properties. The current state of art for making these CNTs involves heating graphite in a high temperature ...
A Story About Light and Energy: Mechanistic and Biosynthetic Investigations of Bioluminescence and Methanogenesis
(2016-12-12)
This dissertation seeks to investigate underexplored aspects of dinoflagellate bioluminescence and biological methane production.
Ubiquitous in the four oceans, dinoflagellate bioluminescence is a consequence of an ...
Exposing the Protein-Protein Interaction Sites and Probing the Flavin Transfer Mechanism in the Alkanesulfonate Monooxygenase System from Escherichia coli.
(2016-01-11)
Sulfur is an essential element for all living organisms. Bacteria acquire sulfur through a sulfur assimilation pathway, but under sulfur limiting conditions bacteria must acquire sulfur from alternative sources. These ...
Resolving the Paradoxical Nature of a Bifunctional Enzyme: Pathways and Regulation of Intramolecular Electron Transfer In KatG
(2016-08-05)
Catalase-peroxidases (KatGs) are heme-dependent enzymes that use a single active site to perform two activities by protein-based radical dependent mechanisms. As a catalase, in its first step, it reduces H2O2 to water and ...
Identifying the Role of His293 in Protein Arginine Methyltransferase 1 and Characterization of Agonists for Peroxisomal Proliferator Activating Receptors
(2016-05-04)
This thesis presents two proteins of interest: (1) protein arginine methyltransferase 1 (PRMT1) and (2) peroxisome proliferator activated receptors (PPARs). The purpose of this thesis is to assess the intermolecular ...
Phospholipid/Aromatic Thiol Hybrid Bilayers
(2016-12-09)
Gold-supported hybrid bilayers comprising phospholipids and alkanethiols have been found to be highly useful in biomembrane mimicking as well as biosensing ever since their introduction by Plant in 1993 (Plant, A. L. ...