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Bipolar Electrodeposition of Bimetallic Alloy (Au-Ag) Gradient: Formation, Characterization and Application
(2017-01-04)
Bipolar electrochemistry is an attention-grabbing conception for high throughput screening practices due to the capability to make gradients in a variety of materials and their properties, such as composition, particle ...
New Dendrimers and Lipids Based on 2,2′-Bi(glycerol), and Lewis Acid Dependent Rearrangements of a Protected Pinacol
(2017-04-25)
Chapter 1: 2,2'-Bi(glycerol), or 2,3-bis(hydroxymethyl)butane-1,2,3,4-tetraol is of interest because of its utility as a potential A6 core for novel dendrimers, and because it may lead to hitherto un¬known 2,2'-bi(triglyceride)s ...
Exploring the Functional Roles of π-helices and Flavin-Induced Oligomeric State Changes in Flavin Reductases of Two-Component Monooxygenase Systems
(2017-04-16)
Sulfur-containing biomolecules participate in various chemical and structural functions in enzymes. When sulfate is limiting, bacteria upregulate ssi enzymes to utilize organosulfonates as an alternative source. The ...
Microfluidic Circuit Designs for Nanoliter-Scale Flow Control and Highly Sensitive Quantitative Bioanalysis
(2017-12-04)
Within this dissertation, we have developed several new microfluidic circuit components that permit precise flow control at the nanoliter scale, and we have demonstrated their successful applications in either proof-of-concept ...
Automated microfluidic device development for metabolism, nutrient uptake, and hormone secretion analyses of primary endocrine tissues
(2017-07-25)
Pancreatic islets secret the dominant endocrine hormone, insulin, which controls the metabolic function fo nearly all other organ systems. Additionally, adipose tissue (fat) is now understood to be a complex, multicellular ...
Development of real-time, quantitative free fatty acid uptake assays for adipose tissue explants using fluorescence and microfluidics
(2017-04-25)
Free fatty acid (FFA) uptake by adipocytes in response to nutritional or hormonal stimuli is a key process in the complex metabolic cascade leading to diabetes and obesity. The work presented in this thesis is focused on ...
Exploring actinide chemistry: uranyl detection and thorium catalysis
(2017-04-21)
In a world where there is a strong need to improve our means of producing energy to sustain our ever expanding population with low green-house emissions, nuclear power offers sustainability and low greenhouse emissions, ...
Novel Lipid Nanoassemblies with Advanced Functionality: Design, Photosynthesis Mimicking and Self-Assembly
(2017-07-31)
Model lipid membranes have attracted considerable attention over the past several decades. They are ideal biomimetic models for studying cells and cellular processes. Due to their unique properties and functional versatility, ...
Towards a Bistable Nucleic Acid-Directed Switch for Electrochemical Readout of Proximity Ligation Assays
(2017-01-04)
The work presented in this thesis is focused on the development of a bistable DNA-driven assay formatted for biosensor applications in biological research, medical research, and an approach to point-of-care testing. We ...
Stable Colloidal Dispersions of Highly Concentrated Thermo-efficient Nanomaterials
(2017-02-08)
Phase change materials (PCM) were utilized as solvents to synthesize small particles and stabilize them in those media in order to determine time independent thermal properties of nanostructure-enhanced phase change materials ...