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Synthesis and Characterization of Tetra- and Penta-dentate Schiff Base Complexes for Application in Actinide Sensing
(2018-07-09)
The advent of the nuclear power era has the potential to provide inexpensive, plentiful
electricity with reduced carbon emissions, but these benefits are offset by concerns about the
potential environmental effects of a ...
The Development of Bipolar Electrochemiluminescence Sensing Systems using Thin-layer Electrochemistry and AC Excitation
(2018-12-10)
Bipolar electrochemistry, which generates an asymmetric reactivity on the surface of conductive objects in a wireless manner, has become a promising field for various applications. It enables the coupling of anodic and ...
Transition from classical methods to new strategies: Mechanistic evaluation of inhibitors against Mycobacterium tuberculosis shikimate kinase
(2018-07-24)
Tuberculosis (TB) still stands as one of the leading causes of mortality resulting from an infectious agent. In part, this stems from the emergence of multidrug and extensive drug-resistant strains of tubercle bacilli, ...
A Non-Cross-Coupling-Based Approach to Arene-Bridged Macrocycles and Their Use in the Development of Annulative Pi-Extension Methods
(2018-07-31)
The synthesis of strained macrocyclic benzene-containing molecules has been an area of interest for decades. However, the synthesis of macrocyclic structures that contain adjacent benzene units linked at their 1 and 4 ...
Towards the formulation of a new multi–determinant electron propagator for open–shell molecular systems
(2018-07-30)
The efforts of this thesis are focused on extending the capabilities of the current single determinant electron propagator formalism to a formulation in which multiple determinants can be employed, enabling the formulation ...
Development of thermally regulated homogeneous assays and droplet-based microfluidic tools for probing secretion dynamics from pancreatic and adipose tissues
(2018-07-24)
Cells can transmit signals and adapt to microenvironment variations rapidly with dynamic
processes, such as biomolecule secretion for signal delivery. Dynamic, oscillatory secretion is
expected to exist in many cell ...
Development of Oligonucleotide, Small Molecule, and Protein Assays using Square-wave Voltammetry with Electrode-bound Nucleic Acid Nanostructures
(2018-01-09)
Biomarker analysis plays a decisive role in health care. This role is not only limited to disease diagnosis, but it also involves understanding of biological and physiological functions in order to monitor health, observe ...
Microfluidic Circuit Designs for Nanoliter-Scale Flow Control and Highly Sensitive Quantitative Bioanalysis
(2018-02-14)
Within this dissertation, we have developed several new microfluidic circuit components that permit precise flow control at the nanoliter scale, and we have demonstrated their successful applications in either proof-of-concept ...
Photoreduction of Chlorinated Organic Pollutants Using Solutions or Films of a Polymeric System via a Free Radical Mechanism
(2018-07-27)
Efficient reduction of chlorinated organics took place upon exposure to 350 nm photons in aqueous solutions containing sulfonated poly(ether etherketone), SPEEK, and either poly(vinyl alcohol), PVA, or HCO2H/HCO2- buffers. ...
Customized Instrumentation for Small-Volume Electrochemistry and Microfluidics used in Bioanalytical Applications
(2018-11-20)
Disease biomarker detection allows diagnosis of both chronic and acute conditions. Although current detection methods are adequate for several targets (e.g. enzymatic biosensors), the stability and limited number of targets ...