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Roles of Large Loops in Catalytic Versatility of Catalase-Peroxidases: Significance of Peripheral Structures in Improvising Enzyme Functions
(2012-05-07)
Catalase-peroxidases are bifunctional enzymes that catalyze the removal of hydrogen peroxide by two distinct pathways (catalase and peroxidase). They are central to antibiotic resistance in Mycobacterium tuberculosis and ...
Structural and Functional Studies to Investigate Enzymatic Catalysis and Flavin Transfer Mechanism of The Two-component Alkanesulfonate Monooxygenase System from Escherichia coli
(2012-05-07)
Several bacterial organisms rely on the two-component alkanesulfonate monooxygenase system for the acquisition of organosulfonate compounds when inorganic sulfur is limiting in the environment. This system is comprised of ...
The Efficiency of Enzymatic L-Cysteine Oxidation in Mammalian Systems Derives from the Optimal Organization of the Active Site of Cysteine Dioxygenase
(2014-04-22)
Intracellular concentrations of free cysteine in mammalian organisms are maintained within a healthy equilibrium by the mononuclear iron-dependent enzyme, cysteine dioxygenase (CDO). CDO catalyzes the oxidation of L-cysteine ...
Lock-In Detection with Microfluidic Droplets for Quantitative Bioanalysis in Sub-Nanoliter Volumes
(2013-11-15)
The following chapters introduce and describe novel droplet microfluidic techniques to assist with limits of detection of analytes with low signal-to-noise ratios. The approach is proven feasible with absorbance measurements ...
Manganese and Iron Coordination Complexes for Biological Imaging and Oxidative Catalysis
(2014-04-23)
The ligand N,N’-bis(2-pyridylmethyl)-bis(ethylacetate)-1,2-ethanediamine (debpn)
coordinates divalent transition metal ions in either a pentadentate or hexadentate fashion. The coordination number correlates with the ionic ...
Structure, dynamics and interaction study of Glutaminase Interacting Protein (GIP) and its complex with Glutaminase L and Brain-specific Angiogenesis Inhibitor 2 (BAI2) peptide and characterization of subunit A of Heterodisulfide Reductase (HdrA) from Methanothermobacter marburgensis
(2013-07-30)
Glutaminase interacting protein (GIP) is a 124 amino acid long protein containing a single PDZ domain. This protein intersects a number of important biological pathways. In many of these pathways, the mechanism of function ...
Investigations into 5ꞌ-Extended 3-Deazaaristeromycin Derivatives
(2014-05-02)
Nucleosides have provided a plentiful source in structural leads in antiviral drug discovery. Included in this class of compounds are the carbocyclic nucleosides, which because of the presence of a cyclopentyl moiety, offer ...
The Extension of Colloid Chemistry from Aqueous to Non-Aqueous Media with Application to Nanofluid Research
(2011-11-17)
Nanofluids are colloids whose design is specific to the study and application of heat transfer systems. Metals typically have thermal conductivities which are several times higher than that of traditional cooling liquids ...
Application of Novel Nanoscale Materials and Advanced Electrochemical Techniques in Heterogeneous Catalysis and Fabrication of Combinatorial Material Libraries by Bipolar Electrodeposition
(2011-09-08)
The advancements in the electrochemical technologies combined with the introduction of novel materials makes our lives a lot better. This work has two major divisions: (1) development of better electrocatalysts for fuel ...
Biophysical characterization of ligand binding and release of Anthereae polyphemus Pheromone Binding Protein 1 (ApolPBP1) and Exploring the nickel proteome
(2013-08-07)
In moths, pheromone binding proteins (PBPs) transport the hydrophobic pheromone molecules to the membrane-bound receptors across the aqueous sensillar lymph to trigger the neuronal response. We showed here that, recombinant ...