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Clinical Applications of Therapeutic Drug Monitoring in Canine Idiopathic Epilepsy Patients Receiving Levetiracetam
(2018-11-20)
There are currently no drugs approved for the treatment of canine idiopathic epilepsy and as a result extra-label use of human-approved medications is common. Older agents such as phenobarbital are effective in dogs, but ...
Effect of Omega 3, 6 and 9 Fatty Acids and Vitamin E on Canine Semen Concentration, Motility, Morphology and Cryopreservation
(2018-07-20)
There are few studies in dogs investigating the efficacy of male fertility supplements, most notably fatty acids. The objective of this study was to investigate the effects of a commercial fatty acid supplement (OM3 Gold ...
Orally administered torsemide in horses: pharmacokinetic and pharmacodynamic studies
(2018-08-02)
Diuretic therapy is the mainstay for management of congestive heart failure in horses. Loop-diuretic medications in horses have been restricted to injectable medications because currently, no data support the use of ...
Kinetic Effects of Heat Stress on Olfaction: A Thermodynamic Evaluation of Electrical Responses to Odorants in Olfactory Epithelia
(2018-04-23)
Detection dogs are exposed to some of the most extreme environmental conditions in the world while simultaneously expected to maintain maximal olfactory function. Sometimes these conditions exceed their thermoregulatory ...
The role of zinc nanoparticles in the initial events of olfaction, their characterization, preservation, and microenvironmental influence.
(2018-04-24)
Olfactory responses are intensely enhanced with the addition of endogenous and engineered primarily-elemental small zinc nanoparticles (ZnNPs). The endogenous ZnNPs have been found as proteon nucleating centers (PNCs) ...
Changes in the Open Reading Frame of Bovine Viral Diarrhea Virus during Serial Infection of Pregnant Cattle, Sheep, and Swine
(2018-04-24)
Bovine viral diarrhea virus (BVDV) is an economically important pathogen that is endemic in cattle populations of many countries. This virus can also infect pigs, camelids, and a wide range of ruminants including sheep, ...
Development and validation of a UPLC-MS method for quantification of selected cannabinoids in canine plasma and its application to commercial cannabis products
(2018-04-24)
Introduction. Cannabinoids are the important chemicals in cannabis plant with medicinal value [51]. However, effective and safe use is best based on studies that describe their behavior in the plasma of the species being ...
Comparison of the gene encoding the thyroid-stimulating hormone receptor between hyperthyroid and non-hyperthyroid domestic cats.
(2018-07-12)
The prevalence of feline hyperthyroidism (FH) is increasing, yet the etiology of FH remains to be elucidated. The purpose of this study was to compare exons 1 to 5 of the thyroid-stimulating hormone receptor (TSHR) gene ...
Diagnosis of feline infectious peritonitis
(2018-02-27)
Feline infectious peritonitis (FIP), a fatal immune-mediated disease, is caused by feline infectious peritonitis virus (FIPV), the high-virulence pathotype of Feline coronavirus (FCoV). It is believed that the FIPV is an ...
Canine and Feline Differences in the Cytochrome P450 Transcriptome and Drug Metabolism
(2018-04-17)
Cytochrome P450 (CYP) is an important enzyme superfamily, estimated to metabolize 70-90% of pharmaceuticals. Use of pharmaceuticals with at least 30% metabolism by CYP in humans require phenotyping to determine the CYP ...