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Methods for Isolating Canine Mast Cell Progenitors, Melanocytes, and Keratinocytes
(2020-04-21)
One of the most difficult aspects of employing precision medicine in the treatment of cancer is determining the best targets to treat within the tumor. A trademark of cancers is that, while two patients may present similar ...
Minimally invasive routes of AAV administration to treat GM1 gangliosidosis
(2020-04-17)
GM1 gangliosidosis is a lysosomal storage disease caused by a deficiency of lysosomal β-galactosidase (βgal), which results in the accumulation of GM1 ganglioside and fatal neurodegeneration. In the human type II (late ...
Australian Labradoodle Dystrophinopathy: A Novel Canine Model for the Study of Duchenne Muscular Dystrophy Cardiomyopathy
(2020-04-22)
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that results in progressive damage to both skeletal and cardiac myocytes. As a result of improved ventilatory care, mortality in affected patients is ...
Multilevel Targeting of Canine Adenovirus Type 2 (CAV2) to Expand Oncolytic Virotherapy in Canine Tumors
(2020-04-06)
Oncolytic virotherapy is a promising therapeutic approach designed to selectively eradicate cancer cells but to spare normal cells. Oncolytic adenoviruses (Ad) are an outstanding and common vehicle for efficient cancer ...
Pharmacokinetics of pimobendan and its metabolite o-desmethyl-pimobendan following rectal administration to healthy dogs
(2020-06-29)
Pimobendan, a benzimidazole-pyridazinone derivative, is an inodilator that is used for the treatment of congestive heart failure in dogs. Pharmacokinetics of pimobendan and its active metabolite o-desmethyl pimobendan ...
Orthobiologic use for equine joint disease
(2020-11-23)
Osteoarthritis (OA) is the leading cause of musculoskeletal disability in people and
Horses. There is a critical need for better understanding of new therapeutics and their effects on the disease. Orthobiologics are ...
Comparison of Tensile Strength and Early Healing of Self-Locking and Surgeon’s Knots for Closure of Ventral Midline Celiotomy in Horses
(2020-07-15)
Characteristics of surgical closure are associated with incisional complications. The surgical knot has been shown to be the weakest point of the suture line. Self-locking knots, such as the forwarder (F) and Aberdeen (A) ...
Diet-induced Gut Microbiome and Colon Transcriptome Changes in C57BL/6J, C57BL/6N and HCA2-/- Mice
(2020-11-24)
Genetic variation drives phenotypic and gut microbiome diversity, while also regulating metabolism and immune responses. C57BL/6J and C57BL/6NCrl inbred mice strains have different metabolic phenotypes in response to ...
Effect of platelet rich plasma lysate and fibroblast growth factor 2 on sperm motility in stallions
(2020-07-14)
Semen extenders are continually tested to improve sperm motility, longevity, and, consequently, improve fertility. Growth factors (GFs) modulate cell function, which could be advantageous to sperm by improving motility. ...
Antimicrobial-resistant bacteria and microbiota identified among flies and their sympatric animals
(2020-07-21)
Antimicrobial resistance is rising globally at an alarming rate as one of the most serious public health challenges. There is increasing evidence that the environment plays a major role in the development and transmission ...