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Phosphodiesterase 5 Inhibition on Dopaminergic and Glutamatergic Neurotransmission: Implications for Memory Enhancement
(2009-02-06)
Phosphodiesterases belongs to a family of proteins that metabolize cyclic nucleotides. There are at present eleven types of Phosphodiesterases been isolated and shown to be expressed in various tissues. Phosphodiesterase ...
Neuroprotection against Methamphetamine Induced Neurotoxicity: Applications for Parkinson’s Disease
(2009-05-04)
Parkinson’s disease is a progressive neurodegenerative disorder associated with selective degeneration of nigrostriatal dopaminergic neurons. It is the most common of the neurodegenerative movement disorders, affecting ...
Insulin Signaling and Synaptic Physiology: Insights into the Pathogenesis of Alzheimer's Disease
(2009-07-07)
An emerging hypothesis is that desensitization of the neuronal insulin receptor (central insulin resistance) may contribute to the pathogenesis of Alzheimer’s disease (AD). It is believed that deficits in glutamatergic ...
Transdermal Delivery of Genistein as a Chemoprotective Drug for Melanoma
(2009-07-13)
Genistein is a soy isoflavone and it is a chemo preventative agent against various cancer cell lines including melanoma. The percutaneous absorption of genistein has been scantly investigated. Also, genistein has very poor ...
Environmental Toxins and Dopaminergic Neurotoxicity: Novel Neuroprotective Strategies
(2009-08-07)
Parkinson's disease (PD) is a progressive degeneration of dopaminergic neurons in the substantia nigra, leading to massive loss of dopamine in the striatum. Environmental and endogenous neurotoxins are implicated the ...
Synthesis of 10, 11, 12, 12a, 12b, 13-Hexahydro-5H-benzo[f]cyclopropa[d]pyrido[1,2-b] Isoquinoline-5,7(9H)dione and Related Compounds
(2009-04-20)
Agents designed to bind with high DNA sequence selectivity offer great
therapeutic opportunities in the treatment of cancer and other genetic disorders. The need
for sequence selective agents arises from the fact that ...
GC-MS and GC-IRD Studies on Ethoxyphenethylamines Related to MDEA, MDMMA and MDBD
(2009-12-17)
Three regioisomeric 3,4-methylenedioxyphenethylamines having the same molecular weight and major mass spectral fragments of equal mass have been reported as drugs of abuse in recent years. These compounds are 3,4-methyle ...