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Roles of Large Loops in Catalytic Versatility of Catalase-Peroxidases: Significance of Peripheral Structures in Improvising Enzyme Functions
(2012-05-07)
Catalase-peroxidases are bifunctional enzymes that catalyze the removal of hydrogen peroxide by two distinct pathways (catalase and peroxidase). They are central to antibiotic resistance in Mycobacterium tuberculosis and ...
Structural and Functional Studies to Investigate Enzymatic Catalysis and Flavin Transfer Mechanism of The Two-component Alkanesulfonate Monooxygenase System from Escherichia coli
(2012-05-07)
Several bacterial organisms rely on the two-component alkanesulfonate monooxygenase system for the acquisition of organosulfonate compounds when inorganic sulfur is limiting in the environment. This system is comprised of ...
Hydrothermal Syntheses, Structures, and Properties of New Iodate and Selenite Compounds of Transition Metals, Lanthanides, and Actinides
(2008-09-09)
Iodate and selenite anions possessing a nonbonding, but stereochemically active lone pairs of electrons, were selected as building blocks to produce new compounds with noncentrosymmetric structures, a prerequisite for ...
Synthesis and Characterization of New Lanthanide Chalcogenides
(2008-09-09)
A large number of new ternary and quaternary lanthanide chalcogenides have been synthesized through solid-state reactions of corresponding elements with the aid of alkali metal halides and Sb2Q3 (Q = S, Se) fluxes. Molten ...
Isoprenoid synthesis: New roles for iron sulfur clusters
(2008-09-09)
Spectroscopic investigations of the GcpE and LytB enzymes involved in the last two steps of the DOXP pathway for isoprene synthesis have been described. YfgB, one of the accessory proteins has also been characterized.
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Exploring sinefungin analogs as potential antiviral agents
(2008-09-09)
Sinefungin bears a strong structural resemblance to S-adenosylmethionine and S-adenosylhomocysteine and, therefore is one of the most potent inhibitors of viral mRNA methyl transferase. Besides antiviral activity, sinefungin ...
Studies to Elucidate the Mechanism of Reduced Flavin Transfer in the Alkanesulfonate Monooxygenase System from Escherichia coli
(2008-09-09)
The two-component alkanesulfonate monooxygenase system utilizes reduced flavin as a substrate to catalyze a unique desulfonation reaction during times of sulfur starvation. The flavin reductase (SsuE) provides reduced ...
Tris(1,3-Dihydroxy-2-propyl)amine, A Planar Trialkylamine: Synthesis, Structure, and Properties. A Potential Precursor to Hypervalent Nitrogen
(2008-09-09)
The hindered amine tris(1,3-dihydroxy-2-propyl)amine, 36, is a potential precursor to possible examples of nitrogen hypervalency. There are no simple, effective, and general methods to synthesize hindered tertiary amines. ...
The Efficiency of Enzymatic L-Cysteine Oxidation in Mammalian Systems Derives from the Optimal Organization of the Active Site of Cysteine Dioxygenase
(2014-04-22)
Intracellular concentrations of free cysteine in mammalian organisms are maintained within a healthy equilibrium by the mononuclear iron-dependent enzyme, cysteine dioxygenase (CDO). CDO catalyzes the oxidation of L-cysteine ...
Lock-In Detection with Microfluidic Droplets for Quantitative Bioanalysis in Sub-Nanoliter Volumes
(2013-11-15)
The following chapters introduce and describe novel droplet microfluidic techniques to assist with limits of detection of analytes with low signal-to-noise ratios. The approach is proven feasible with absorbance measurements ...