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Evaluation of Bacillus biocontrol potential through the lens of secondary metabolite diversity in genomic, enzymatic, and chemical space
(2022-08-04)
Global food security is under threat by plant-pathogenic oomycetes and fungi. The overuse and misuse of pesticides against such pathogens triggers fungicide resistance and long-term environmental contamination. This warrants ...
Dual Mode Redox-Responsive MRI Contrast Agents
(2022-08-05)
Magnetic resonance imaging (MRI) contrast agents function by shortening the relaxation
times of targeted nuclei, thereby better distinguishing regions with different local concentrations
of the visualized nuclei. ...
The Modification and Role of a Methyl-Arginine Post-Translational Modification in the Active Site of the Enzyme Methyl-Coenzyme M Reductase
(2022-12-02)
The enzyme methyl-coenzyme M reductase (Mcr) is used in methanogenic archaea to produce methane and in anaerobic methanotrophs to oxidize methane. A significant portion of the methane produced by methanogens is released ...
KATG as a Defense Against Hydrogen Peroxide Toxicity: From a Redundant C-Terminal Domain to the Paradoxical Synergy of Two Mutually Antagonistic Activities
(2014-12-09)
Catalase-peroxidases (KatGs), first discovered in 1979, are heme-dependent enzymes mainly found in bacteria, archaea and fungi. They are capable of decomposing H2O2 by catalatic and peroxidatic pathways. KatG has garnered ...
Investigating a novel protein-based cofactor: toward elucidating the catalase mechanism of Mycobacterium tuberculosis KatG
(2022-12-07)
Catalase-peroxidases (KatGs) have been engineered by nature to exhibit dual functionalism, degrading H2O2 by catalase and peroxidase mechanisms. This serves to protect the organisms that carry it (primarily bacteria and ...
Computational Studies of Dinoflagellate Luciferase and Radical S-adenosyl-L-methionine Enzymes
(2022-12-06)
This dissertation seeks to apply computational methods to study two enzymatic systems: dinoflagellate luciferase and radical S-adenosyl-L-methionine enzymes. Dinoflagellates are microorganisms, many of which are capable ...
Catalase-Peroxidase: A Structure that Facilitates Electron Transfer, Protein-based Cofactor Formation, and Antibiotic Activation
(2022-12-09)
Catalase-peroxidase (KatG) is a heme-dependent enzyme that uses a single active for the degradation of H2O2 by two distinct mechanisms. One is a catalase mechanism where two equivalents of H2O2 are disproportionated with ...
Investigation of Large Protein Complexes Important for Methyl-Coenzyme M Reductase Activity and Function
(2022-12-07)
Methyl-coenzyme M reductase (Mcr) is a key enzyme of methanogens that catalyzes the production or consumption of methane. Mcr contains a nickel tetrapyrrole cofactor (coenzyme F430) which has a crucial role in catalysis. ...
Biocatalytically And Photoelectrochemically Driven Active Motion of Liposomes
(2023-02-17)
Self-propelled artificial micro/nanomotors are currently attracting increased interest as not only mimics of biological motors but also potential components of nanomachinery, robotics, and sensing devices. In regards to ...
JANUS LIPOSOMES: DESIGN, FORMATION AND ACTIVE MOTION
(2023-03-08)
The liposome is an amphiphilic molecule that contains both a hydrophilic head and a hydrophobic tail. As a class of biocompatible, water-dispersed colloids, liposomes have found widespread applications ranging from food ...