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Functional Roles of Conserved Active Site Amino Acids in the Desulfonation Reaction Catalyzed by the Alkanesulfonate Monooxygenase from Escherichia coli
(2009-02-23)
The flavin-dependent alkanesulfonate monooxygenase (SsuD) catalyzes the oxidation of 1-substituted alkanesulfonates producing sulfite and a corresponding aldehyde in the presence of O2 and FMNH2. The reduced flavin is ...
Carbocyclic C-Nucleosides Derived from Formycin
(2009-02-23)
Analogs of naturally occurring nucleosides have served as structural models for the design of antitumor, antiviral, and antibacterial agents. Some modified nucleosides have become major therapeutic agents for the treatment ...
Synthetic Explorations to Sinefungin Analogs
(2009-02-23)
Sinefungin, a natural complex nucleoside, has been isolated from the cultures of Streptomyces griseolous, and from that of Streptomyces incarnatus. It is a structural analog of S-adenosylmethionine (AdoMet) and since its ...
Studies on the Structures and Properties of Bimetallic Uranium Transition Metal and Hybrid Organic-Inorganic Compounds
(2009-06-15)
Hydrothermal synthetic methods have been utilized to synthesize many compounds containing both uranium and transition metals, as well as hybrid organic-inorganic materials. These compounds are found to adopt zero-, one-, ...
Preparation and Application of Regenerable N-Halamine Biocidal Materials
(2009-05-06)
Copolymers of an N-halamine siloxane and a quaternary ammonium salt siloxane were prepared using 5,5-dimethylhydantoin and trimethylamine as functional groups. The solubility of this siloxane copolymer in water was ...
Role of Distant, Intrasubunit Residues in Catalase-Peroxidase Catalysis: Tracing the Role of Gene Duplication and Fusion in Enzyme Structure and Function
(2009-05-08)
In spite of being positioned 30 Å away from the active site, the C-terminal domain is essential for catalase-peroxidase (KatG) function. Addition of equimolar amounts of separately expressed and isolated C-terminal domain ...
Activation and Inhibitor Studies on Methyl-Coenzyme M Reductase and Purification of a New Hydroxylamine Oxidoreductase from Methylomicrobium Album ATCC 33003
(2009-02-23)
Methyl-coenzyme M reductase (MCR) catalyzes the formation of methane from methyl-coenzyme M (CH3-S-CoM) and coenzyme B (HS-CoB) in methanogenic archaea. In order to manage the overproduction of methane in the environment, ...
Spectroscopic and kinetic investigation of two unusual structural features found in eukaryotic cysteine dioxygenase
(2009-12-17)
Cysteine dioxygenase (CDO) is a mononuclear ferrous enzyme located at a branch-point in cysteine metabolism and catalyzes the oxidation of L-cysteine using both atoms of dioxygen. Although several studies have attempted ...
Synthesis, Spectroscopic Investigation and Immobilization Of Copper(II) Complexes as Oxidation Catalysts
(2009-08-04)
Schiff-base complexes that function as catalysts in aqueous media have been developed. The design of environmentally benign metal catalysts with multidentate ligands is a field of intense current interest. Transition metal ...
Toward a Breathable Fabric for Protection Against Airborne Toxic Chemicals, and an Olefin-Forming Cascade Reaction En Route to 2,2’-Bi(glycerol)
(2009-07-31)
Part I. Several compounds that were envisioned to interact strongly with airborne chemical warfare agents, principally organophosphorus nerve agents, were synthesized. This was part of a multi-site, multi-investigator ...