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Microwave Promoted Addition of Organosiloxanes to Hydroxyl Containing Substrates for Facile Synthesis of Chemical and Biological Warfare Agent Reactive Polymers
(2009-02-23)
The primary focus of this work was the synthesis and characterization of materials efficacious in detoxifying/killing chemical and/or biological threat agent surrogates, including Bacillus anthracis spores, in militarily ...
Synthesis and Application of Novel Biocidal Materials
(2009-02-23)
For this study, a new N-halamine, 1-(2, 3-epoxypropyl)-6-methyluracil, was synthesized and was coated onto cotton fabric. The treated cotton was then activated by chlorination using Clorox bleach. The cotton swatches were ...
Seeking MRNA Methylation Inhibitors as Antiviral Agents
(2009-02-23)
Aristeromycin and neplanocin A are two examples of potent S-adenosylhomocysteine hydrolase inhibitors. As a consequence, they show significant broad-spectrum antiviral activity, however, their clinical potential is limited ...
Probing the Reaction Mechanism of Methyl Coenzyme M Reductase
(2009-02-23)
Methyl coenzyme M reductase (MCR) is the key enzyme in both microbial methane production and anaerobic methane oxidation. MCR catalyzes the reaction of methyl-coenzyme M (CH3SCoM) and coenzyme B (HSCoB) to methane and the ...
Electrocatalytic and Antibacterial Applications of Sandwich Type Polyoxometalates
(2009-02-23)
The primary goal of this dissertation is to study the structure-property relationship of sandwich type polyoxometalates and to employ these versatile molecules in electrocatalytic applications such as oxygen generation and ...
Design and Synthesis of AdoHcy Hydrolase Inhibitors as a Source of Antiviral Agents
(2009-02-23)
The significant antiviral properties of the carbocyclic nucleosides aristeromycin and neplanocin A have been attributed to inhibition of AdoHcy hydrolase, which in turn affects viral mRNA capping methylation. However, their ...
Surface Plasmon Assisted Spectroscopies and Their Application in Trace Element Analysis, the Study of Biomolecular Interactions, and Chemical Sensing
(2008-09-09)
The main objective of this dissertation is to apply the fundamental principles of surface plasmon assisted spectroscopies such as surface plasmon resonance spectroscopy and surface enhanced Raman spectroscopy in the trace ...
Towards the Understanding of Complex Biochemical Systems: the Significance of Global Protein Structure and Thorough Parametric Analysis
(2009-07-06)
Enzymes are a highly diverse set of macromolecules, and, given their size and biocatalytic significance, each is an extremely complex system to study. As such, many assumptions must be made to simplify these systems to a ...
Functional Roles of Conserved Active Site Amino Acids in the Desulfonation Reaction Catalyzed by the Alkanesulfonate Monooxygenase from Escherichia coli
(2009-02-23)
The flavin-dependent alkanesulfonate monooxygenase (SsuD) catalyzes the oxidation of 1-substituted alkanesulfonates producing sulfite and a corresponding aldehyde in the presence of O2 and FMNH2. The reduced flavin is ...
Carbocyclic C-Nucleosides Derived from Formycin
(2009-02-23)
Analogs of naturally occurring nucleosides have served as structural models for the design of antitumor, antiviral, and antibacterial agents. Some modified nucleosides have become major therapeutic agents for the treatment ...