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Development of a sustained-release voriconazole-containing thermogel for subconjunctival injection in horses
(2016-08-03)
Subconjunctival administration of a slow-release, voriconazole-containing thermogel may allow for sustained delivery of voriconazole to the cornea and anterior chamber.
Thermogel development consisted of four ...
Equine Endothelial Colony Forming Cells: In Vitro and In Vivo Analysis
(2019-07-24)
Endothelial colony forming cells (ECFCs) are a subset of the endothelial progenitor cell (EPC). EPCs are found in bone marrow and in peripheral blood samples, and their subset the ECFC can be isolated from these samples ...
Canine and Feline Differences in the Cytochrome P450 Transcriptome and Drug Metabolism
(2018-04-17)
Cytochrome P450 (CYP) is an important enzyme superfamily, estimated to metabolize 70-90% of pharmaceuticals. Use of pharmaceuticals with at least 30% metabolism by CYP in humans require phenotyping to determine the CYP ...
Ex vivo comparison of the bursting strength of surgeon’s knot compared to self-locking knots for closure of ventral midline celiotomy in horses.
(2018-07-27)
It is not uncommon for the equine population to experience abdominal pain referred to as
‘colic’. It is estimated that approximately 9% of the general population of horses that experience
colic require surgical intervention. ...
Multilevel Targeting of Canine Adenovirus Type 2 (CAV2) to Expand Oncolytic Virotherapy in Canine Tumors
(2020-04-06)
Oncolytic virotherapy is a promising therapeutic approach designed to selectively eradicate cancer cells but to spare normal cells. Oncolytic adenoviruses (Ad) are an outstanding and common vehicle for efficient cancer ...
Pharmacological characterization and functional rescue of the giant panda and human melanocortin-4 receptors
(2017-07-25)
The melanocortin-4 receptor (MC4R) is a member of family A rhodopsin-like G protein-coupled receptors. It is well established that MC4R is critically involved in regulating food intake and energy expenditure in mammals. ...
Prevention and Pathogenesis of Avian Infectious Bronchitis: The Role of Infectious Bronchitis Virus Spike Proteins in Cell Attachment and Protective Immunity
(2017-12-01)
Infectious bronchitis virus (IBV) evolves by genetic diversity and selection resulting in continuous emergence of new virus phenotypes. Spike (S) protein is responsible for virus entry. The S1 subunit of the S glycoprotein ...
Phage-GnRH Constructs for Population Control of Feral Animals: Evaluation in Cats
(2018-11-15)
The overpopulation of cats is a problem in the United States and worldwide due to public health concerns and their role as a predator of wildlife species. The focus of this research is the development of anti-fertility ...
A Biodegradable Microparticle Vaccine Platform using Femtomole Peptide Antigen Doses to Elicit T-cell Immunity against Chlamydia abortus
(2016-12-20)
Successful vaccination against Chlamydia spp. has remained elusive, largely due to a lack of vaccine platforms for the required Th1 immunization. Modeling of T helper cell immunity indicates that Th1 immunity requires ...
Differential Effects of Niacin on Adipose Tissue Inflammation, Hepatic Function, and Gut Microbiota Composition in C57BL/6J and B6129SF2/J Mice
(2019-07-18)
Background. Obesity is associated with adipose tissue inflammation, development of nonalcoholic fatty liver disease (NAFLD) and altered gut microbiota composition. Niacin is beneficial in inhibiting obesity-associated ...