Skip to Navigation
Auburn University Homepage
A-Z Index | Map | People Finder
Auburn University Logo
Electronic Theses and Dissertations
Skip to Main Content
Main Navigation 
  • AUETD Home
  • Graduate School
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  •   AUETD Home
  • View Item
  •   AUETD Home
  • View Item

Mass Spectral, Infrared and Chromatographic Studies on Homologs and Regioisomers of 3,4-Methylenedioxypyrovalerone (MDPV)

View/Open
Extracted text (160.0Kb)
Younis's Masters Thesis (2.137Mb)
Date
2012-07-25
Author
Abiedalla, Younis
Type of Degree
thesis
Department
Pharmacal Sciences
Metadata
Show full item record
Abstract
A series of 10 homologous and regioisomeric aminoketones related to the designer synthetic cathinone derivative MDPV were synthesized. These compounds were all prepared from a common precursor chemical, piperonal (3,4 methylenedioxybenzaldehyde). The analytical properties of these compounds were compared by GC-MS and GC-IR techniques. These aminoketones show major fragments in their mass spectra corresponding to the regioisomeric and homologous immonium cation fragments. All these compounds in this study show equivalent EI MS fragments for the 3,4-methylenedioxybenzoyl fragments (m/z 149) and the methylenedioxybenzene fragment )m/z 121). The vapor phase infrared spectra allow for the differentiation of the regioisomers of mass spectral equivalence. The regioisomeric aminoketones yield equivalent mass spectra including mass equivalent regioisomeric immonium cation base peak which is identical to that of the designer drug MDPV. An evaluation of the effects of homologation on gas chromatographic retention showed that addition of a methylene (CH2) in the nitrogen-containing ring increases retention more than the equivalent group added to the alkyl side-chain.
Files
Name:
Younis's Masters Thesis.pdf.txt  
Size:
160.0Kb
Name:
Younis's Masters Thesis.pdf  
Size:
2.137Mb
URI
http://hdl.handle.net/10415/3252

Browse

All of AUETDBy Issue DateAuthor / AdvisorTitlesDepartments

My Account

Login

Auburn University Libraries | 231 Mell Street | Auburn, Alabama 36849 | (334) 844-4500 or (800) 446-0387 |

 

Auburn University |Auburn, Alabama 36849 |(334) 844-4000 |

Website Feedback |Privacy |Copyright ©