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Studies on The Synthesis of B-Ring 6-Azasteroids
Date
2006-08-15Author
Gandikota, Jyothi
Type of Degree
ThesisDepartment
Chemistry and BiochemistryMetadata
Show full item recordAbstract
Azasteroids, which carry a nitrogen in the C-6 position of the steroid nucleus are still
mysterious and very few synthesized, were found to possess antimicrobial and antifungal
properties apart from their pharmacodynamic actions. The literature reports for
synthesizing these compounds is also very limited. We developed different approaches
and modified, streamlined procedures for the synthesis of these compounds. The target
molecules had different side chains (R= H, Me, Et) at the 6th position and were
synthesized using ozone and other oxidizing agents. The oxidative cleavage of the B-ring
was the key step to insert a nitrogen atom.