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Molecular Mechanisms of Neuroprotection by an Alternative Drug Scutellaria lateriflora


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dc.contributor.advisorKemppainen, Barbara W.
dc.contributor.advisorSchwartz, Dean D.
dc.contributor.advisorJoiner, Kellye
dc.contributor.advisorDhanasekaran, Muralikrishnan
dc.contributor.advisorVan Ginkel, Frederik
dc.contributor.authorLohani, Madhukar
dc.date.accessioned2014-07-21T15:59:44Z
dc.date.available2014-07-21T15:59:44Z
dc.date.issued2014-07-21
dc.identifier.urihttp://hdl.handle.net/10415/4273
dc.description.abstractAnxiety is one of the most prevalent neuropsychological disorders around the world. In the United States of America (USA), it is a serious health problem affecting a large number of people and is considered as one of the common disorder seen in the primary health care. Based on the current understanding of the pathologic mechanisms of anxiety, there are limited pharmacological and non-pharmacological therapies. Benzodiazepine (the current first line of therapy) has severe adverse effects such as anterograde amnesia, tolerance, psychomotor impairment, memory disruption, impaired psychomotor function, paradoxical anxiety or aggression, risks of accidents and even mortality. A double blind, placebo-controlled clinical trial indicated that commercial preparations of Scutellaria lateriflora have therapeutic benefits in anxiety with no evidence of toxicity. The purpose of this study was to examine the biological activities of S. lateriflora that may contribute to its neuroprotective mechanisms. The research study was conducted in four phases. The first two experimental approaches determined anti-oxidative potential and protective activities of S. lateriflora against oxidative stress induced neuronal cell death. The third experimental approach was designed to examine anti-inflammatory and immunomodulatory activities of S. lateriflora. Finally, we examined the effects of Scutellaria lateriflora on synaptic plasticity in the form of long-term potentiation (LTP). S. lateriflora exhibited anti-oxidative, anti-inflammatory and immunomodulatory activities, however, it suppressed synaptic plasticity. These results indicate neuroprotective activities of S. lateriflora against oxidative stress induced cell death and have anti-inflammatory activities.en_US
dc.rightsEMBARGO_NOT_AUBURNen_US
dc.subjectVeterinary Medicineen_US
dc.subjectVeterinary Anatomy, Physiology, and Pharmacologyen_US
dc.titleMolecular Mechanisms of Neuroprotection by an Alternative Drug Scutellaria laterifloraen_US
dc.typedissertationen_US
dc.embargo.lengthMONTHS_WITHHELD:12en_US
dc.embargo.statusEMBARGOEDen_US
dc.embargo.enddate2015-07-21en_US

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