Chemokine Receptor CXCR7 in Vascular Biology and Disease
| Metadata Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | Shen, Jianzhong Jr | |
| dc.contributor.author | Wang, Chuan Jr | |
| dc.date.accessioned | 2018-04-16T21:32:59Z | |
| dc.date.available | 2018-04-16T21:32:59Z | |
| dc.date.issued | 2018-04-16 | |
| dc.identifier.uri | http://hdl.handle.net/10415/6104 | |
| dc.description.abstract | Initially CXCR4 was thought to be the exclusive receptor for SDF-1. However, the discovery of a new SDF-1 receptor CXCR7, made the picture more complex. Whether CXCR7 is a “scavenger” receptor or not is still in debate. The biased signaling pattern on CXCR7 has not been determined. The aim of my study is to prove that CXCR7 is not just a scavenger receptor but instead, it can induce cell signaling in a time- and ligand-dependent biased mechanism, unveiling potential role of CXCR7 in vascular biology and disease. | en_US |
| dc.rights | EMBARGO_GLOBAL | en_US |
| dc.subject | Pharmacy | en_US |
| dc.title | Chemokine Receptor CXCR7 in Vascular Biology and Disease | en_US |
| dc.type | PhD Dissertation | en_US |
| dc.embargo.length | MONTHS_WITHHELD:60 | en_US |
| dc.embargo.status | EMBARGOED | en_US |
| dc.embargo.enddate | 2023-04-16 | en_US |