|Advanced manufacturing has resulted in significant changes on the shop-floor, influencing
work demands and the working environment. The corresponding safety-related impacts, including
fatigue, have not been fully captured on an industry-wide scale. The objectives of this
dissertation are to understand the current state of workers’ physical fatigue in the manufacturing
sector, and suggest evidence-based interventions that can be applied at workplaces.
Specifically, these objectives were investigated through two studies. In the first study, a
cross-sectional survey of U.S. manufacturing workers was conducted and analyzed to examine
the prevalence of fatigue, its root causes and significant associated factors, as well as the
individual fatigue coping methods adopted by survey participants. This study has been disseminated
to the research community through a journal paper. The second study was a systematic
review of existing controlled clinical trials to grade the methodological quality of the studies
and assess the levels of evidence on interventions. Overall, this research aims to inform the
design of fatigue monitoring and mitigation strategies as well as suggest future research related
to fatigue development.