Elucidate the Neuro-Pharmacodynamic Actions of 3-Hydroxypterostilbene
Metadata Field | Value | Language |
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dc.contributor.advisor | Dhanasekaran, Muralikrishnan | |
dc.contributor.author | Kadannagari, Surekha | |
dc.date.accessioned | 2022-11-29T19:35:54Z | |
dc.date.available | 2022-11-29T19:35:54Z | |
dc.date.issued | 2022-11-29 | |
dc.identifier.uri | https://etd.auburn.edu//handle/10415/8477 | |
dc.description.abstract | Pterostilbene (dimethyl ether analog of resveratrol) is a metabolically stable natural bioactive and has exhibited substantial pharmacological activities. 3-Hydroxypterostilbene is a natural pterostilbene analog and an active metabolite of Pterostilbene. The current literature reveals antimicrobial (anti-fungal), anti-obesity, and anti-cancer (skin, leukemia, and colon) activities. However, there are no reports on the actions of 3-Hydroxypterostilbene on the central nervous system. Consequently, there is a void in the neuropharmacological effect of 3-Hydroxypterostilbene. Therefore, this study investigated the pharmacodynamic effect of 3-Hydroxypterostilbene on the dopaminergic and hippocampal neurons. Additionally, in-silico analyses were performed to validate its neuro-pharmacodynamic effects. The in-silico studies revealed its ability to cross the blood-brain barrier and in-vitro studies established the ability to significantly inhibit the dopaminergic and hippocampal neuronal viability. 3-Hydroxypterostilbene induced significant neurotoxicity (hippocampal and dopaminergic neuronal death) by enhancing apoptosis (Caspase-3 activity) and by inhibiting tyrosine hydroxylase activity without inducing oxidative stress and mitochondrial dysfunction. | en_US |
dc.rights | EMBARGO_NOT_AUBURN | en_US |
dc.subject | Interdepartmental Pharmacy | en_US |
dc.title | Elucidate the Neuro-Pharmacodynamic Actions of 3-Hydroxypterostilbene | en_US |
dc.type | Master's Thesis | en_US |
dc.embargo.length | MONTHS_WITHHELD:12 | en_US |
dc.embargo.status | EMBARGOED | en_US |
dc.embargo.enddate | 2023-11-29 | en_US |
dc.contributor.committee | Moore, Timothy | |
dc.contributor.committee | Pondugula, Satyanarayana | |
dc.contributor.committee | Ramapuram, Jayachandra | |
dc.creator.orcid | N/A | en_US |