Advancing Cancer Treatment: Nano-Based Therapy and Innovative Evaluation Platform

Abstract

Cancer continues to be a predominant cause of mortality despite extensive research efforts. The intricate microenvironment surrounding cancer poses formidable challenges for effective treatment strategies. In response to this, the fields of nanomedicine and immunotherapy have emerged as promising avenues for innovative cancer therapies. This dissertation presents a comprehensive exploration of these approaches through a series of studies encapsulated in five chapters. Chapter 1 serves as an introductory overview, providing a contextual background for the research projects undertaken. This section delineates the persistent challenges in cancer treatment and highlights the significance of exploring advanced methodologies such as nanomedicine and immunotherapy. The subsequent three research chapters (Chapters 2-4) delve into specific investigations. Chapter 2 addresses the integration of photothermal therapy and chemotherapy as a combined treatment modality for triple-negative breast cancer. This research explores the synergistic effects of these two therapeutic approaches to enhance treatment efficacy and potentially overcome the challenges associated with triple-negative breast cancer. In Chapter 3, attention was directed towards the utilization of DQ liposomes in conjunction with copper for the treatment of prostate cancer. The study aimed to investigate the potential benefits of this combined approach, offering insights into novel formulations that may improve treatment outcomes in prostate cancer patients. Chapter 4 explored immunotherapy for leukemia and an assessment of associated side effects using an advanced integrated organ-on-chip platform. This research investigated cutting-edge immunotherapeutic strategies for leukemia and addressed the crucial aspect of evaluating and mitigating potential adverse effects through innovative organ-on-chip technology. Finally, Chapter 5 serves as the conclusion, summarizing the key findings and insights from the research endeavors. Additionally, this chapter outlined future directions for further exploration, emphasizing the potential for advancements in nanomedicine and immunotherapy to reshape the landscape of cancer treatment. The comprehensive nature of this dissertation contributes to the ongoing discourse on novel therapeutic modalities, providing a foundation for future research and potential clinical applications in the relentless pursuit of more effective cancer therapies.