Browsing by Author "Huggins, Kevin"

Now showing items 21-32 of 32

Pro-Nerve Growth Factor Induced RhoA Kinase Activation in PC12 Cells

Sycheva, Marina (2017-07-27)

Alzheimer’s Disease (AD) is characterized by neurodegeneration and progressive decline in memory, cognition and independence. Nerve Growth Factor (NGF) is the neurotrophin responsible for mediating neuronal survival and ...

The protective effects of stearidonic acid on adipogenesis and neurotoxicity

Li, Yueru (2017-01-04)

Abstract The ω-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in fish oil have been reported to have protective effects on metabolic syndrome-related diseases, such ...

Resting Metabolism and Metabolic Responses to Solid and Liquid Meals in Sedentary and Exercising College-Age Males

Ratcliff, Lance (2008-08-15)

Differences in resting metabolic rate (RMR) were measured in a total of 29 sedentary and exercising college-age males, as were their metabolic responses (diet-induced thermogenesis, DIT) to solid and liquid meals. Subject ...

Role of calcium-independent phospholipase A2 in insulin-stimulated glucose uptake in 3T3-L1 adipocytes

Yang, Juan (2009-08-06)

Calcium-independent phospholipase A2 (iPLA2) is a member of the phospholipase A2 family that catalyzes the hydrolysis of glycerophospholipid at the sn-2 position to liberate free fatty acid and lysophospholipid. Recent ...

The Role of Polyubiquitination in Nerve Growth Factor Signaling and its Alteration in Alzheimer’s Disease

Zheng, Chen (2016-08-05)

Nerve growth factor (NGF) is a neurotrophin regulates survival and differentiation of neurons. To execute its antiapoptotic function, NGF binds to selective receptor TrkA and non-selective receptor p75NTR, leading to TrkA ...

The Role of Sugar-sweetened Water in the Progression of Nonalcoholic Fatty Liver Disease

Luo, Yuwen (2016-12-08)

Nonalcoholic fatty liver disease (NAFLD), which ranges from simple steatosis (fatty liver) to nonalcoholic steatohepatitis (NASH), has become the most common chronic liver disease in both children and adults, paralleling ...

Sequestosome 1/p62 and TRAF6 are necessary for Akt ubiquitination, translocation and activation

Carter, Andrea (2014-11-24)

Defects in protein-protein interactions of the insulin signaling pathway result in insulin resistance that precedes type 2 diabetes. The protein Akt is the primary modulator of cellular glucose uptake through the GLUT4 ...

Ser312 Fetuin-A Phosphorylation and Its Association with Serum Lipids in Metabolic Syndrome

Kaushik, Shalini (2008-08-15)

Fetuin-A (also known as alpha 2-HS-glycoprotein), secreted by the liver into circulation, interacts with the insulin receptor, and is a physiological inhibitor of insulin receptor tyrosine kinase activity in vitro, in ...

Therapeutic effects of aniracetam on cognitive deficits induced by ethanol teratogenicity: A novel treatment approach through synaptic AMPA receptor modulation

Wijayawardhane, Nayanakanthi (2007-05-15)

Ethanol exposure during fetal development can adversely affect the outcome of the offspring. Numerous mechanisms are likely to contribute to these damaging effects of ethanol on the fetus and particularly the developing ...