Browsing by Department "Chemistry and Biochemistry"
Now showing items 21-40 of 219
Characterization of the iron center in cysteine dioxygenase and kinetic analyses of flavin binding by the alkanesulfonate flavin reductase
(2006-12-15)
Cysteine dioxygenase (CDO) and the flavin reductase, SsuE, are both important proteins in sulfur metabolism. CDO catalyzes cysteine oxidation which is a key step in cysteine metabolism in mammalian systems. SsuE is a flavin ...
Characterization of the mechanism of 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH)
(2013-08-21)
In this thesis, two projects were carried in the context of understanding the reaction mechanism of 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (also called HMBPP reductase or IspH).
The first project is the ...
Characterization of Two-component Organothiol Mixed Monolayers on Gold and Quantification of Nonspecific Adsorption on Mixed Sam Biosensor Platforms Using Electrochemical Enzyme Immunoassay
(2007-05-15)
Self-assembled monolayer (SAM) technology provides a simple and useful way to functionalize biosensors. The formation and characterization of SAM monolayers are briefly reviewed in Chapter One. Several selected examples ...
Chemically Modified Electrodes: A Supramolecular Assembly Approach
(2008-12-15)
The main objective of this dissertation is to design and study new superamolecular assemblies for membrane separation, sensing and catalysis applications. Three types of supramolecular assemblies will be addressed including ...
Chemistry in silico: Organic Reactions, Ionic Liquids, Tautomerization
(2013-04-22)
Computational chemistry is a collection of methods that seek to interpret and predict chemical phenomena. In this work, three distinct areas of chemistry are investigated: (1) the reactive pathways of UVA irradiated ...
Computational Investigation of Condensed Phase Properties of Ionic Systems
(2012-04-17)
Four computational studies have been performed with various computational techniques including density functional theory, post-HF theory, and implicit solvation modeling to investigate the dehydrogenation mechanism of ...
A Computational Mechanistic Study of an Aza-Michael Addition and a Paal-Knorr Reaction
(2015-01-13)
Computational chemistry is a rapid growing branch of chemistry that seeks to interpret chemical problems and predict chemical phenomena using mathematical approximations and computer programs. In the present work, we ...
Computational Studies of Dinoflagellate Luciferase and Radical S-adenosyl-L-methionine Enzymes
(2022-12-06)
This dissertation seeks to apply computational methods to study two enzymatic systems: dinoflagellate luciferase and radical S-adenosyl-L-methionine enzymes. Dinoflagellates are microorganisms, many of which are capable ...
Coordination Complexes with Redox-Active Macrocyclic Ligands as Redox-Responsive 1H and 19F MRI Contrast Agent Sensors and Catalysts for the Degradation of Hydrogen Peroxide
(2023-05-02)
Abstract
Reactive oxygen species (ROS), including hydroxyl radicals (·OH), superoxide anions (O2-), and hydrogen peroxide (H2O2), play vital roles in cell signaling and cellular signal transduction; however, the ...
Copper(II) 2-Quinoxalinol Salen Type Ligands as Catalysts for C-H Oxidation Reactions
(2020-04-09)
C-H oxidation is a powerful tool that has changed the face of synthetic organic chemistry over the last several years. Here, we explore the oxidation of alkynes to α,β-acetylenic carbonyls using only 1 mol % of an inexpensive ...
Copper(II)-Mediated 2-Quinoxalinol Salens in Alcohol Oxidation and C-H Activation: A Greener Approach
(2014-07-11)
Reduction of waste production in chemical processes is the idea of greener chemistry by using less toxic or benign methods and eliminating purification steps. Because of this, using a catalytic rather than stoichiometric ...
Crossroads and Terminations in Transuranium Chemistry
(2008-08-15)
The focus of this dissertation is published results from my doctoral research at Auburn University, the scope of which is multifaceted. The first topic covers recent research devoted to developing a better understanding ...
Customized Instrumentation for Small-Volume Electrochemistry and Microfluidics used in Bioanalytical Applications
(2018-11-20)
Disease biomarker detection allows diagnosis of both chronic and acute conditions. Although current detection methods are adequate for several targets (e.g. enzymatic biosensors), the stability and limited number of targets ...
A Cyclophane-Based Approach to [n]Cycloparaphenylenes and an Allylic Arylation Strategy for Regioselective Triphenylene Synthesis
(2019-04-17)
CHAPTER 1 Synthesis of functionalized p-terphenyl-containing macrocycles as key intermediates in the synthesis of functionalized [n]CPPs
Strategically designed, substituted para-terphenyl-containing macrocycles are ...
A Cyclophane-Based Approach to Highly Strained [n]Cycloparaphenylenes and Synthesis of Hexa-substituted Pyrenes and Their Application to Polycyclic Aromatic Hydrocarbon Synthesis
(2022-05-02)
Chapter 1: The synthesis of highly strained carbon nanoring, [4]CPP and its potential precursor has been an ever-increasing level of interest in the past few decades. The biggest challenge in CPP synthesis is macrocyclization ...
Design and Properties of Novel Uranium-Containing Layered and Framework Materials
(2006-12-15)
Ten uranyl-containing frameworks and one layered material have been
synthesized under hydrothermal conditions. These compounds belong to eight structure
types, not previously described. They are constructed from uranyl ...
Design and Synthesis of 3-Deazaaristeromycin Derivatives
(2010-12-07)
Analogs of naturally occurring nucleosides have served as structural models for the design of antitumor, antiviral, and antibacterial agents. The carbocyclic nucleosides aristeromycin and neplanocin A are two examples that ...
Design and Synthesis of AdoHcy Hydrolase Inhibitors as a Source of Antiviral Agents
(2008-05-15)
The significant antiviral properties of the carbocyclic nucleosides aristeromycin and neplanocin A have been attributed to inhibition of AdoHcy hydrolase, which in turn affects viral mRNA capping methylation. However, their ...
The Design, Synthesis and Application of Redox-Responsive MRI Contrast Agents
(2015-07-29)
Reactive oxygen species (ROSs), such as hydroxyl radicals, superoxide anions and hydrogen peroxide, are side products of aerobic respiration. Although ROSs regulate several physiological processes, they have been implicated ...
Development and Application of New Platforms for Oligonucleotide and Protein Assays
(2020-07-20)
Sensitive and rapid detection of infectious disease is becoming very significant to improve human health. We have seen that the sensitive methods often required expensive, and sophisticated instruments. Biosensors are ...