This Is AuburnElectronic Theses and Dissertations

Browsing by Department "Pharmacal Sciences"

Now showing items 21-40 of 44

Insulin Signaling and Synaptic Physiology: Insights into the Pathogenesis of Alzheimer's Disease 

Shonesy, Brian (2009-07-07)
An emerging hypothesis is that desensitization of the neuronal insulin receptor (central insulin resistance) may contribute to the pathogenesis of Alzheimer’s disease (AD). It is believed that deficits in glutamatergic ...

LC-MS based metabolite fingerprinting and profiling of a traditional Chinese medicine YANG XIN® formulation 

Almalki, Ahmad (2015-07-29)
For thousands of years, Traditional Chinese Medicine (TCM) has been used to treat or prevent various diseases, for this reason western countries have been attracted to and use TCM together with allopathic medicine. YANG ...

Macrophage CXCR7: A Potential New Target for Atherosclerosis 

Ma, Wanshu (2013-07-15)
Objective—The discovery of CXCR7 as a new receptor for SDF-1 places many previously described SDF-1 functions attributed to CXCR4 in question, though whether CXCR7 acts as a signaling or “decoy” receptor has been in debate. ...

Mass Spectral and Chromatographic Studies on a Series Of Regioisomers and Isobaric Derivatives Related to Methylenedioxymethamphetamines 

Awad, Tamer (2006-12-15)
The popular drug of abuse 3,4-methylenedioxymethamphetamine (MDMA) has regioisomeric and isobaric substances of mass equivalence, which have similar analytical properties and thus the potential for misidentification. Direct ...

Mass Spectral, Infrared and Chromatographic Studies on Designer Drugs of the Piperazine Class 

Hafiz Abdel-Hay, Karim (2012-02-20)
The controlled drug 3,4-methylenedioxybenzylpiperazine (3,4-MDBP) has regioisomeric and isobaric substances of mass equivalence, which have similar analytical properties and thus the potential for misidentification. The ...

Mass Spectral, Infrared and Chromatographic Studies on Homologs and Regioisomers of 3,4-Methylenedioxypyrovalerone (MDPV) 

Abiedalla, Younis (2012-07-25)
A series of 10 homologous and regioisomeric aminoketones related to the designer synthetic cathinone derivative MDPV were synthesized. These compounds were all prepared from a common precursor chemical, piperonal (3,4 ...

Mechanisms Underlying Myeloperoxidase Inhibition: Evaluating the Efficacy and Safety of Anti-inflammatory MPO Inhibitors Designed to Limit the Generation of Reactive Oxygen and Nitrogen Species 

Huang, Jiansheng (2015-07-24)
Myeloperoxidase (MPO), a heme-containing peroxidase, plays a critical role in the innate immune response by producing hypochlorous acid. MPO-mediated oxidation is also associated with chronic obstructive pulmonary disease ...

Microneedles Assisted Iontophoretic Transdermal Delivery of Drugs 

Pawar, Kasturi (2013-11-01)
Topical/transdermal delivery offers an attractive alternative to oral and parenteral delivery in terms of non-invasiveness, administration and termination of dose and drug stability etc. However, the excellent barrier ...

Molecular Mechanisms of Neuroprotection and Cognitive Enhancement by an Alternative drug Centella asiatica 

Ahuja, Manuj (2013-04-22)
Complementary and Alternative medicine (CAM) is increasingly gaining enormous importance as a part of current day therapeutic regimen for various incurable, chronic neurological disorders, majorly because of the palliative ...

Molecular mechanisms underlying synaptic dysfunction in Aging Alzheimer's disease and Diabetes 

Kariharan, Thiruchelvam (2012-01-19)
Alzheimer’s disease (AD) and diabetes (DB) contribute to the development of early brain aging and cognitive dysfunction. Mechanistic basis of cognitive dysfunction in AD and DB is not well elucidated. Resistance to age ...

Neuroprotection against Methamphetamine Induced Neurotoxicity: Applications for Parkinson’s Disease 

Thrash, Bessy (2009-05-04)
Parkinson’s disease is a progressive neurodegenerative disorder associated with selective degeneration of nigrostriatal dopaminergic neurons. It is the most common of the neurodegenerative movement disorders, affecting ...

Nicotine and Integrin Linked Kinase Interplay Modulates Synaptic Plasticity Mechanisms Required for Memory 

Aljadani, Fatimah (2015-09-23)
Integrin Linked Kinase (ILK) has been associated with forms of synaptic plasticity required for memory. Nicotine, at low-concentration improves memory but higher concentrations impart learning and memory deficits. The ...

Non-platelet Purinergic Signaling and Tissue Factor Expression 

Liu, Yiwei (2015-12-14)
Objective—Our group found previously that human coronary artery endothelial P2Y2 receptor mediates tissue factor (TF) up-regulation at mRNA and protein levels. The exact mechanism remains unknown and can involve increased ...

Pharmacokinetics of Voriconazole in Horses and Alpacas 

Chan, Hui (2008-05-15)
Voriconazole is a new antifungal drug that has shown effectiveness in treating serious fungal infections and has the potential for being used in large animal veterinary medicine. The objectives of this study were to ...

Phosphodiesterase 5 Inhibition on Dopaminergic and Glutamatergic Neurotransmission: Implications for Memory Enhancement 

Uthayathas , Subramaniam (2009-02-06)
Phosphodiesterases belongs to a family of proteins that metabolize cyclic nucleotides. There are at present eleven types of Phosphodiesterases been isolated and shown to be expressed in various tissues. Phosphodiesterase ...

Prenatal Nicotine Exposure and Glutamatergic-Cholinergic Interplay 

Buabeid, Manal (2013-12-02)
Smoking in pregnant women is reported as a risk factor in neurobehavioral alterations such as learning and memory deficits. Prenatal exposure of nicotine (6mg/kg /day) in animal models induces memory impairment associated ...

Prenatal Nicotine Exposure and Molecular Mechanisms of Memory Impairment 

Parameshwaran, Kodeeswaran (2008-08-15)
Prenatal nicotine exposure in the form of active maternal smoking is a major risk factor for several harmful effects in the children. These effects include reduced motor skills, poor IQ scores and most importantly learning ...

Promethazine Orally Disintegrating Tablet 

Graben, Roger (2006-05-15)
Orally Disintegrating Tablets (ODTs) which disintegrate rapidly (< one minute) in the mouth and do not require water for administration have become a very popular dosage form. Current methods of manufacturing ODTs are ...

Role Of Integrin-Linked Kinase In Synaptic Plasticity And Memory:o Diabetes/Alzheimer’s Link 

Ali, Engy (2012-05-03)
Type 2 diabetes mellitus (T2DM) has recently been proven to be a risk factor for cognitive dysfunction and dementia such as Alzheimer’s disease (AD). However, the exact pathophysiology of cognitive dysfunction in patients ...

Synaptic Glutamate Receptor Dysfunction in Tissue and Animal Models of Alzheimer’s Disease 

Kanju, Patrick (2005-08-15)
The complexity of cognitive decline involved in Alzheimer’s disease (AD) warrants a thorough investigation into the molecular mechanism that may hold the basis for the impaired learning and memory. Indeed, certain molecules ...