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LC-MS based characterization of Mycobacterium tuberculosis shikimate kinase inhibitors containing oxadiazole-amide and aminobenzothiazole rings
Alturki, Mansour (2016-07-26)
The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has increased the demand for the discovery of new antitubercular drugs. The shikimate pathway is essential ...
Molecular modeling, design, and synthesis of some potential selective DNA minor groove alkylators
Alturki, Mansour (2021-12-03) ETD File Embargoed
Small molecules-DNA interactions are responsible for many biological processes. The DNA present in normal and tumor cells are almost identical. Therefore, DNA targeting drugs are used only in serious and life-threatening ...