Browsing by Author "Amin, Rajesh"

Now showing items 1-13 of 13

Adiponectin alters hippocampal synaptic function: a mechanism for amelioration of synaptic deficits in a mouse model of Alzheimer’s disease

Bloemer, Jenna (2019-12-06)

The hormone adiponectin, the most abundant adipokine, is an important regulator of metabolic function, and recent evidence suggests that adiponectin plays an essential role in the cross-talk between adipose tissue and brain ...

Elucidating the Cognitive Deficits following Doxorubicin treatment

Alhowail, Ahmad (2014-12-11)

Chemotherapeutic drugs are effective in the treatment of various types of tumors; however, the optimal clinical effectiveness is limited due to secondary effects including cognitive impairment, also known as “chemobrain”, ...

Experimental woodsmoke exposure during exercise and an evaluation of blood oxidative stress

Peters, Bridget (2015-05-18)

Introduction: Woodsmoke exposure and exercise elicit oxidative stress in blood. The purpose of this investigation was to understand the effects of woodsmoke exposure on blood oxidative stress measures. Methods: Ten males ...

Identification of A New Pharmacological Modulator for P2Y2 Receptor Activity

Alsadah, Eiman (2018-04-23)

P2Y2 is a G-protein-coupled membrane receptor activated by ATP or UTP nucleotides. They play major roles in cellular physiology in different aspects including inflammatory responses and apoptosis. Therefore, P2Y2 receptor ...

Investigating the Role of Aging and Pathological Tau in Alzheimer's Disease

Setti, Sharay (2021-12-06) ETD File Embargoed

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by accumulation of plaques made of insoluble beta-amyloid protein, neurofibrillary tangles containing hyperphosphorylated tau protein, ...

Molecular mechanisms underlying synaptic dysfunction in Aging Alzheimer's disease and Diabetes

Kariharan, Thiruchelvam (2012-01-19)

Alzheimer’s disease (AD) and diabetes (DB) contribute to the development of early brain aging and cognitive dysfunction. Mechanistic basis of cognitive dysfunction in AD and DB is not well elucidated. Resistance to age ...

Nicotine and Integrin Linked Kinase Interplay Modulates Synaptic Plasticity Mechanisms Required for Memory

Aljadani, Fatimah (2015-09-23)

Integrin Linked Kinase (ILK) has been associated with forms of synaptic plasticity required for memory. Nicotine, at low-concentration improves memory but higher concentrations impart learning and memory deficits. The ...

Precision Medicine Based on Real-time Immune Status Profiling Utilizing Novel Nanoparticles and Engineered Nanomaterials

Cai, Yuxin (2023-04-03)

Cancer treatment strategies such as Anti-programmed death-ligand 1 (Anti-PD-L1) or chimeric antigen receptors (CAR) T-cells are limited by low objective response rates and severe side effects. This is partly due to the ...

Regulation of SLC19A3 thiamin transporter by HIF-1α

Yooket, Pattanin (2016-08-04)

Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that regulates gene expression in response to hypoxia, including SLC19A3, thiamine transporter 2, a facilitative carrier that mediates intracellular uptake ...

Role of Chemokine Receptor CXCR7 in Adipocyte Physiology and Disease

Shi, Yi (2022-04-14) ETD File Embargoed

Objective—Chemokines and chemokine receptors have long been shown to play important roles in inflammation, obesity, and type II diabetes. CXCR7 is characterized as an atypical chemokine receptor whose function as a signaling ...

The Role of Frataxin in Doxorubicin Mediated Cardiac Hypertrophy

Mouli, Shravanthi (2016-07-29)

Doxorubicin (DOX) is a highly effective anti-neoplastic agent, used to treat a wide range of cancer. However, the clinical application of DOX is limited due to its dose dependent cardiotoxic complications which eventually ...

Role Of Integrin-Linked Kinase In Synaptic Plasticity And Memory:o Diabetes/Alzheimer’s Link

Ali, Engy (2012-05-03)

Type 2 diabetes mellitus (T2DM) has recently been proven to be a risk factor for cognitive dysfunction and dementia such as Alzheimer’s disease (AD). However, the exact pathophysiology of cognitive dysfunction in patients ...

Selective PPARγ agonism attenuates pathologies and improves cognitive deficits in Alzheimer's disease

Govindarajulu, Manoj (2020-07-31) ETD File Embargoed

The continuous increase association of Alzheimer's disease (AD) with the increasing aged population and mortality rate indicates an unmet medical need and the critical need for establishing novel molecular targets for ...