Browsing by Author "Arnold, Robert"

Now showing items 1-13 of 13

Application of Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) for Lipid-based Nanomedicine Development

Nie, Ben (2017-04-25)

Secretory phospholipase A2 (sPLA2) are increased in various cancers. The lipid specificity and reactivity of sPLA2 and its ability to interact with PLA2 receptors (PLA2R) are potential targets for development of liposome ...

Assessment of Tofacitinib and Ruxolitinib and their Anti Inflammatory Effects on Myeloperoxidase

Milton, Amber (2017-07-27)

Abstract Myeloperoxidase (Mpo) is a heme-containing enzyme present in inflammation. Mpo catalyzes the production of hypochlorous acid (HCLO) by reacting with hydrogen peroxide (H2O2) and chloride (Cl-). Mpo together ...

Deep tissue imaging of B16 melanoma in mice by Multispectral Optoacoustic Tomography

Bahauddin, Ammar (2022-06-23) ETD File Embargoed

Melanoma is an aggressive type of skin cancer that can metastasize to draining lymph nodes and distant organs. Early detection of melanoma holds the promise of improved patient outcomes by enabling earlier surgical ...

Determine the Anticancer Activity and Mechanism of Overcoming Drug Resistance by Cu(DDC)2 NPs in Prostate Cancers

Wang, Junwei (2021-07-14) ETD File Embargoed

Copper diethyldithiocarbamate [Cu(DDC)2] complex formed by disulfiram (DSF) and copper ions is a promising therapeutic agent for cancer treatment. However, the poor aqueous solubility of Cu(DDC)2 limited its clinical ...

Effect of Extended Exposure Topotecan on Drug Resistance Using a Novel 3D Spheroidal Model of Castrate-Resistant Prostate Cancer

Davis, Joshua (2023-04-24)

Cancer consistently commands the highest number of therapeutic drug approvals each year, however, this has yet to yield significant clinical benefits for metastatic disease. Instead, most drugs are likely to increase ...

ERBB4 is a Driver of BRAF WT Melanomas

Lucas, Lauren (2023-04-28)

Approximately 50% of metastatic melanomas harbor a BRAF V600 mutation which causes elevated RAF/MEK/ERK pathway signaling. These tumors are treated using a combination of a BRAF and MEK inhibitor which targets the canonical ...

Nonequilibrium Thermodynamics and Fitness Costs Associated with Information Preservation May Explain Longevity Differences between Species

Augsburger, Brett (2016-05-05)

The aging process in most organisms is enormously complex, involving a multitude of integrated molecular pathways that define and modulate the gradual cellular, tissue and system-level changes that evoke the aging phenotype. ...

Pharmacokinetic Modeling for In Vitro/In Vivo Transdermal Absorption

Lee, Yann-Huei (2017-11-29)

The objective was to determine if a linear pharmacokinetic model could be developed to describe in vitro and in vivo transdermal absorption across normal and microporated skin. Such a model would enable formulators to ...

Real-time Monitoring of Staphylococcus Aureus Biofilm Formation Under Flow Conditions in Microfluidic Chambers

Al Mouslem, Abdulaziz Khalid (2020-07-21) ETD File Embargoed

Staphylococcus aureus (S. aureus) causes most of life-threatening infections such as endocarditis, osteomyelitis and sepsis. Since biofilm development is often a key factor in the development of an infection of indwelling ...

Selection of Promiscuous Anti-Cancer Phage Proteins for Tumor Targeted Nanomedicines

Gross, Amanda (2015-07-28)

Cancer remains one of the leading causes of death and requires novel approaches in both management and treatment. Tumor targeting ligands have been identified to a variety of human cancer cell lines using phage display ...

Short-Chain Ceramides for Enhancing Cytotoxicity of Liposome-Encapsulated Doxorubicin Toward Human Breast Cancer (MDA-MB-231) and Prostate Cancer (PC-3) Cells

Alrbyawi, Hamad (2016-08-01)

Co-delivery of short chain ceramide, C6-Ceramide (C6-Cer) and C8-Ceramide (C8-Cer) and doxorubicin (DOX) using a liposomal system in MDA-MB-231 breast cancer and PC3 prostate cancer cell lines for synergistic cytotoxic ...

Strategies for Monitoring Pathologic Conditions and Treatment Efficacy in Murine Models

Brannen, Andrew (2016-12-09)

On the surface, the pathologies of infectious disease and cancer appear fundamentally different; however, there exist several commonalities including pharmacological targets and resistance mechanisms, immune response, and ...

Tissue Engineered Cancer Models for in vitro Recapitulation of the Native Tumor Microenvironment

Habbit, Nicole (2018-07-18)

Despite having been first documented over 5000 years ago, cancer remains one of the most prevalent and lethal diseases to plague the human race to date. According to the National Cancer Institute, nearly half of Americans ...