Browsing by Author "Bird, Richard"

Now showing items 1-11 of 11

Development of functional capacity and bactericidal activity in myeloid cells during GM-CSF driven differentiation

Olatunde, Adesola (2018-07-18)

Dendritic cells (DC) form an interface between the innate and adaptive immune systems. DC respond to infection or inflammatory signals by orchestrating other immune cells to perform protective functions. These include ...

ERBB4 is a Driver of BRAF WT Melanomas

Lucas, Lauren (2023-04-28)

Approximately 50% of metastatic melanomas harbor a BRAF V600 mutation which causes elevated RAF/MEK/ERK pathway signaling. These tumors are treated using a combination of a BRAF and MEK inhibitor which targets the canonical ...

Identification and isolation of five developmental stages in GM-CSF-stimulated murine bone marrow culture.

Rogers, Peter (2018-04-24)

Dendritic cells (DCs) are highly potent cells that link the innate immunity with the adaptive. However, these cell types (and their precursors) are extremely rare in vivo. Considerable work has been done to map the development ...

Investigating HCAR and FAN1 Variants as Inherited Risk Factors of Breast Cancer

McGuire Sams, Cierla (2022-04-22) ETD File Embargoed

Inherited genetic risk factors in known breast cancer (BC) susceptibility genes increase an individual’s overall lifetime risk of developing BC but explain only ~35% of hereditary BC cases. Therefore, additional BC ...

The Lactocrine Hypothesis and Laser Microdissection: Evaluating Tissue-Specific Effects of Milk-Borne Factors on Gene Expression in the Neonatal Porcine Uterus

Miller, Dori (2014-05-29)

In the pig, development of the uterus begins in utero and is promoted postnatally via communication of milk-borne bioactive factors (MbFs) that advance development of neonatal somatic tissues. The passage of MbFs from ...

Methods for Isolating Canine Mast Cell Progenitors, Melanocytes, and Keratinocytes

Flaat, Taylor (2020-04-21)

One of the most difficult aspects of employing precision medicine in the treatment of cancer is determining the best targets to treat within the tumor. A trademark of cancers is that, while two patients may present similar ...

microRNA as Predictive Biomarkers of Canine Mammary Tumors

Fish, Eric (2019-07-18)

Canine mammary tumors (CMT) are one of the most common forms of cancer in intact female dogs. CMTs share clinical, epidemiologic, and genetic features with women with breast cancer (BC). BC and CMT cells have altered ...

Multilevel Targeting of Canine Adenovirus Type 2 (CAV2) to Expand Oncolytic Virotherapy in Canine Tumors

Sajib, Abdul Mohin (2020-04-06)

Oncolytic virotherapy is a promising therapeutic approach designed to selectively eradicate cancer cells but to spare normal cells. Oncolytic adenoviruses (Ad) are an outstanding and common vehicle for efficient cancer ...

Nonequilibrium Thermodynamics and Fitness Costs Associated with Information Preservation May Explain Longevity Differences between Species

Augsburger, Brett (2016-05-05)

The aging process in most organisms is enormously complex, involving a multitude of integrated molecular pathways that define and modulate the gradual cellular, tissue and system-level changes that evoke the aging phenotype. ...

Novel Approaches to the Molecular Characterization of Primary Canine Osteosarcoma

Nance, Rebecca (2023-07-24) ETD File Embargoed

Osteosarcoma (OSA) is an aggressive malignant bone tumor that often affects pediatric humans as well as dogs. Canine OSA shares many similarities with the human condition, including clinical presentation and molecular ...

Selection of Promiscuous Anti-Cancer Phage Proteins for Tumor Targeted Nanomedicines

Gross, Amanda (2015-07-28)

Cancer remains one of the leading causes of death and requires novel approaches in both management and treatment. Tumor targeting ligands have been identified to a variety of human cancer cell lines using phage display ...