Browsing by Author "Boothe, Dawn"

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Cannabinoid: A Potential Anti-Cancer Agent for Non-Hodgkin Lymphoma

Omer, Saba (2021-07-23)

The non-Hodgkin lymphomas (NHLs) are a heterogeneous family of lymphoid malignancies and are one of the most commonly diagnosed neoplasm in both dogs and humans. Systemic anticancer chemotherapy is the treatment of choice ...

Clinical Applications of Therapeutic Drug Monitoring in Canine Idiopathic Epilepsy Patients Receiving Levetiracetam

Bunn, Haden (2018-11-20)

There are currently no drugs approved for the treatment of canine idiopathic epilepsy and as a result extra-label use of human-approved medications is common. Older agents such as phenobarbital are effective in dogs, but ...

Determination of Safe and Effective Dosing Regimens for Nonsteroidal Anti-inflammatory Drugs in African and Asian Elephants.

Kottwitz, John-Ryan (2019-07-29) ETD File Embargoed

Arthritis and foot disease are well documented conditions affecting captive elephants that are frequently treated with nonsteroidal anti-inflammatory drugs (NSAIDs). An important consideration regarding efficacy and safety ...

Disposition of levetiracetam in healthy adult horses

Cesar, Fernanda (2014-07-11)

Nine horses received 20 mg/kg of intravenous LEV (LEVIV), 30 mg/kg of intragastric, immediate release LEV (LEVIR) and extended release (LEVER), in a 3-way randomized crossover design. Serum samples were collected over 48 ...

The Effect of Mutations in Type II Topoisomerases on Fluoroquinolone Resistance in Clinical Canine Urine Escherichia coli Isolates

Behringer, Megan (2011-04-12)

A series of experiments were preformed in order to validate a rapid FRET-PCR based assay for the detection of fluoroquinolone resistance in small animal Escherichia coli urinary tract infection (UTI) isolates. Three hundred ...

Fluoroquinolone-associated mutations in soxS, a transcriptional regulator of AcrAB efflux pump

Lazzaroni, Caterina (2013-11-08)

Escherichia coli is a major cause of urinary tract infections in companion animals and efflux pump over expression has been associated with high-level fluoroquinolone (FQ) resistance. The purpose of this study was to ...

Impact of Antimicrobial Therapy on Fecal Escherichia coli in Dogs

Debavalya, Nipattra (2009-05-05)

Antimicrobial resistance is an emerging aspect of antimicrobial therapy. However, few studies have documented this relationship in vivo. The purpose of this study was to describe the relationship between antimicrobial ...

Molecular Epidemiology and Genetic Analysis of Staphylococcus species in Companion Animal Medicine

Diaz-Campos, Dubraska (2012-05-01)

In human medicine, methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of bacterial infections in the United States (191). In veterinary medicine, an increased number of multidrug-resistant ...

Novel Analgesics and the Impact of Route of Administration in the Horse

Davis, Heather (2019-12-05)

primary goal of this dissertation was to describe the disposition of novel analgesics and the impact of their administration on the equine patient. In order to support this aim, a novel, non-septic, transient model of ...

Pharmacokinetics and Pharmacodynamics of Enrofloxacin and Low-dose Amikacin after Regional Intravenous Limb Perfusion in Standing Horses

Sanchez, Alberto (2006-08-15)

Objective - To evaluate the tisular pharmacokinetics/dynamics of enrofloxacin and low-dose amikacin after regional intravenous limb perfusion (RILP) in standing horses. Animals – Fourteen adult horses Procedures – ...

Pharmacokinetics of intraperitoneal infusion of lidocaine in horses

de Estrada, Joaquin (2012-07-31)

The objective of this study was to describe the pharmacokinetics of intraperitoneal (IP) lidocaine in horses (30mg/kg). The study was designed as double blinded cross-over, placebo controlled clinical trial, with a 2 weeks ...

Pharmacokinetics of pimobendan and its metabolite o-desmethyl-pimobendan following rectal administration to healthy dogs

Her, Jiwoong (2020-06-29)

Pimobendan, a benzimidazole-pyridazinone derivative, is an inodilator that is used for the treatment of congestive heart failure in dogs. Pharmacokinetics of pimobendan and its active metabolite o-desmethyl pimobendan ...

The Role of gyrA, Efflux Pump and Integrons in Mediating the Emergence of Multi-Drug Resistance among Canine and Feline Pathogenic Clinical Escherichia coli

Shaheen, Bashar (2009-05-01)

A series of experiments was performed to elucidate the emergence of fluoroquinolone (FQ)/multi-drug resistance (MDR) and the contribution of selected mechanisms of resistance to MDR (i.e. mutations in gyrA, efflux pump, ...

Therapeutic Drug Monitoring and Population Analysis as Applied to Leflunomide and Cyclosporine Therapy in Dogs with Immune-mediated Diseases

Sofge, Jameson (2014-09-10)

Two immunomodulator drugs, leflunomide (teriflunomide is its active metabolite) and cyclosporine, are often monitored in veterinary patients in order to support the design of dosing regimens when used to treat immune-mediated ...