Browsing by Author "Brown, Michael"

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Association of DNA Copy Number and Structural Variation with Racial Disparities in Childhood Obesity

Phillips, Megan (2021-04-21) ETD File Embargoed

Obesity has become a major public health concern throughout the world. Alabama is 6th highest ranked with obesity in the United States. The development of obesity can be influenced by several factors, such as diet, ...

Differences between linear volume resistance training versus variable resistance training in skeletal muscle molecular adaptations

Fox, Carlton (2021-07-07)

Although several studies have examined the strength and hypertrophy adaptations in response to lower versus higher volume resistance training, examining the metabolic and morphological adaptations that occur to both forms ...

Effects of Shear Stress on Oxidized LDL Modulation of miRNA Expression in African American and Caucasian Endothelial Cell Lines

Rumbley, Melissa (2022-05-05) ETD File Embargoed

Endothelial dysfunction is a leading cause of atherosclerosis and cardiovascular disease (CVD). Oxidized LDL (oxLDL) and microRNAs (miRNAs) have been shown to play crucial roles in the development and progression of ...

Effects of The Hexosamine Biosynthesis Pathway in Endothelial Function

Adeyemo, Adelola (2019-12-09) ETD File Embargoed

Diabetes is characterized by high circulating plasma glucose and insulin resistance. Many diabetics have additional comorbidities, a major one being hypertension. Endothelial dysfunction links diabetes and hypertension. ...

Immune-Associated Chronic Inflammation: Biological Responses Between Endothelial Cells and T Cells Following Treatment with Thymus vulgaris and Eugenia caryophyllata Essential Oils

Clifton, Christie (2022-11-29)

Chronic inflammation is associated with autoimmune disorders and chronic diseases such as diabetes and cardiovascular disease. Prolonged interaction between circulating leukocytes (CD4+ T cells) and microvasculature ...

An Introduction to Bernstein-Gel’fand-Gel’fand Correspondence

Dixon, Robert (2022-08-04)

This master's thesis serves as an introduction to the Bernstein-Gel'fand-Gel'fand correspondence first written in 1978. We shall cover some of the fundamental objects that the reader may not be familiar with, mainly tensor ...

An investigation of the mitochondria as a potential source of racial differences in reactive oxygen species production and cellular respiration in peripheral blood mononuclear cells of healthy adults

Gomez, Dulce (2022-04-11) ETD File Embargoed

Background: Non-Hispanic Black (NHB) adults exhibit a higher prevalence of cardiovascular disease (CVD) compared to Non-Hispanic White (NHW) adults. Vascular oxidative stress may be one contributing factor to these racial ...

Line-1 Retrotransposition and the Impact on Aging Rodent Skeletal Muscle Tissue

Mumford, Petey (2019-04-16)

Purpose: Long INterspersed Element 1 (LINE-1) is a class 1 transposable element known as a retrotransposon. LINE-1 is thought of as a genomic parasite due to its reverse transcription machinery, and ability to randomly ...

Novel Kidney Injury Biomarkers in Young Adults

Barnett, Alex (2021-08-09)

Chronic kidney disease (CKD) is a condition in which gradual kidney damage impairs its ability to filter blood. CKD has varying levels of severity and tends to become more common, and worsen, with advanced age. If left ...

Role of TNFR I Signaling in Racial Differences in Endothelial Function: Potential Modulatory Effect of High Laminar Shear Stress

Aldokhayyil, Maitha (2020-12-02)

In the endothelium, TNF binding to TNF receptor I (TNFR I) instigate a cascade of inflammatory events that facilitate monocytes recruitment and consequently initiation of atherosclerosis. In addition, TNF promotes endothelial ...