Browsing by Author "Byrne, Mark E."

Now showing items 1-9 of 9

Biohybrid and Biomimetic Platforms for Programmable Therapeutic Delivery

Venkatesh, Siddarth (2008-08-15)

Drug and gene delivery carriers such as hydrogels and metallic nanoparticles have shown remarkable promise as programmable platforms in the targeted delivery of their payload. In this work, the fundamental principles of ...

Development and Screening of Targeted Anticancer Nanomedicines

Gillespie, James William (2015-07-29)

Cancer remains a significant healthcare burden worldwide and novel strategies to improve treatment outcomes with improved patient quality of life are needed. Recently, nanomedicines, which encapsulate a therapeutic drug ...

Engineering Polymer Networks for Enhanced Loading and Extended Release of Therapeutics via Molecular Imprinting

Tieppo Rappo, Arianna (2013-12-10)

Conventional topical ocular therapies such as eye drops and ointments are the current “go to” therapy, and account for over 90% of the market. However, topical drug delivery results in very low drug bioavailability, ranging ...

Novel Bio-Hybrid Nanoscale Carriers Engineered for High Therapeutic Payload and Controllable Extended Release Using Nucleic Acid Aptamers

Mohana Sundaram, Padma Priya (2014-05-02)

Controlled delivery of therapeutics to target tissues constitutes a great challenge of modern medicine, especially in the field of cancer treatment where malignant cells have to be killed without damaging the surrounding ...

The Rational Design of Recognitive Polymeric Networks for Sensing Applications

Noss, Kimberly RyAnne (2009-05-04)

Testosterone recognitive networks were synthesized with varying feed crosslinking percentages and length of the bi-functional crosslinking agent to analyze the effect of changing structural parameters on template binding ...

Reaction Analysis of Templated Polymer Systems

Vaughan, Asa (2008-08-15)

Templated polymer systems have unique 'trained' binding characteristics that make them of high interest within chromatography, sensors, diagnostic devices, and drug delivery carriers. In this work, a typical highly ...

Simultaneous Controlled Release Of Multiple Comfort Molecules And The Production Of Novel High Comfort Contact Lens Materials Through Biphasic Molecular Imprinting

White, Charles, Jr. (2014-12-10)

Contact lens induced dry eye (CLIDE) affects approximately 80% of contact lens wearers. Extrapolating to the world wide population of 300 million contact lens wearers, there are approximately 200 million wearers who express ...

Size Optimization of Magnetic Nanoparticles for Biomedical Applications via a Novel Size- Selective Fractionation Process

Rogers, Hunter (2014-12-12)

Magnetic nanoparticles, especially those composed of iron oxide, are extremely attractive options when it comes to MRI contrast agents and magnetically targeted therapies. Their superparamagnetic properties as well as their ...

Therapeutic Contact Lenses for Comfort Molecules

Ali, Maryam (2007-12-15)

Dry eye syndrome affects nearly 15% of the population and can cause extreme discomfort that interferes with quality of life. Current treatment options include delivering comfort agents such as hyaluronic acid (HA) to the ...