Browsing by Author "Clark, Randall"

Now showing items 1-16 of 16

Application of Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) for Lipid-based Nanomedicine Development

Nie, Ben (2017-04-25)

Secretory phospholipase A2 (sPLA2) are increased in various cancers. The lipid specificity and reactivity of sPLA2 and its ability to interact with PLA2 receptors (PLA2R) are potential targets for development of liposome ...

Applications of Mass spectrometry in natural product drug discovery for malaria: Targeting Plasmodium falciparum thioredoxin reductase

Munigunti, Ranjith (2013-04-23)

Malaria is considered to be the dominant cause of death in low income countries especially in Africa. Malaria caused by Plasmodium falciparum is a most lethal form of the disease because of its rapid spread and the development ...

Assessment of Tofacitinib and Ruxolitinib and their Anti Inflammatory Effects on Myeloperoxidase

Milton, Amber (2017-07-27)

Abstract Myeloperoxidase (Mpo) is a heme-containing enzyme present in inflammation. Mpo catalyzes the production of hypochlorous acid (HCLO) by reacting with hydrogen peroxide (H2O2) and chloride (Cl-). Mpo together ...

Computational Modeling, Design and Synthesis of Selective Cannabinoid Receptor 2 (CB2) Agonists

Neel, Logan (2021-12-08)

Synthetic cannabinoids that are synthesized and used recreationally are a world-wide health problem. They are synthesized in order to mimic the euphoric effects similar to THC, but due to the higher affinity at the cannabinoid ...

Discovery and characterization of synthetic and natural compounds as inhibitors of shikimate kinase from Mycobacterium tuberculosis by LC-MS

Simithy, Johayra (2014-12-10)

With the increasing emergence of drug-resistant tuberculosis (TB) and the complication by HIV co-infection, Mycobacterium tuberculosis (Mtb) remains a challenging target for drug discovery. The shikimate pathway, responsible ...

Elucidating the Neurotoxic Effects of Piperazine Derivatives in Human Neuroblastoma Cells through Oxidative Stress, Mitochondrial Dysfunction and Apoptosis

Katz, Daniel (2015-07-24)

Designer drugs are synthetic structural analogues/congeners of controlled substances with slightly modified chemical structures intended to mimic the pharmacological effects of known drugs of abuse so as to evade drug ...

Establishment and optimization of the LC-MS-based strategy for screening of passively absorbed açaí and maca constituents for CYP3A4 inhibition

Rants'o, Thankhoe Abram (2017-07-27)

The escalation of cancer morbidity and mortality has increased the use of botanical dietary supplements among cancer patients undergoing chemotherapy. Euterpe oleracea Mart. (açaí) berry and Lepidium meyenii Walpers (maca) ...

The establishment of the Alabama Hereditary Cancer Cohort and genetic analysis

Bishop, Madison (2018-11-16)

Inherited genetic risk factors in known breast cancer (BC) susceptibility genes increase an individual’s overall lifetime risk of developing BC and are estimated to contribute towards approximately 35% of hereditary BC ...

Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling

Darakjian, Lucy (2020-05-14)

In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...

GC-MS Studies on Methoxymethylene- Substituted Phenethylamines Related to MDA, MDMA, MDEA and MDMMA

NIng, Yu (2012-07-25)

This thesis mainly focused on synthesis and analysis approaches of eight methoxymethylene phenethylamine compounds associated with MDMA and MBDB series structures. Gas chromatography- mass spectrometry (GC-MS) methods were ...

Investigate the dopaminergic neurotoxicity profile of designer drugs (Piperazine derivatives)

Almaghrabi, Mohammed (2018-05-14)

Different botanical derived, or synthetic addictive substances have been “misused” and/or “abused” for centuries around the world. To overcome the abuse by these substances, strict legal laws were constituted globally. ...

LC-MS based characterization of Mycobacterium tuberculosis shikimate kinase inhibitors containing oxadiazole-amide and aminobenzothiazole rings

Alturki, Mansour (2016-07-26)

The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has increased the demand for the discovery of new antitubercular drugs. The shikimate pathway is essential ...

LC-MS based metabolite fingerprinting and profiling of a traditional Chinese medicine YANG XIN® formulation

Almalki, Ahmad (2015-07-29)

For thousands of years, Traditional Chinese Medicine (TCM) has been used to treat or prevent various diseases, for this reason western countries have been attracted to and use TCM together with allopathic medicine. YANG ...

Mass Spectral, Infrared and Chromatographic Studies on Homologs and Regioisomers of 3,4-Methylenedioxypyrovalerone (MDPV)

Abiedalla, Younis (2012-07-25)

A series of 10 homologous and regioisomeric aminoketones related to the designer synthetic cathinone derivative MDPV were synthesized. These compounds were all prepared from a common precursor chemical, piperonal (3,4 ...

Revalidating DNA Damage Inducible 1 Homolog II (DDI2) as a Novel Target for the Treatment of Cancer

Ibtisam, Ibtisam (2023-05-04)

Cancer cells are under proteotoxic stress and are more sensitive to the perturbation of protein quality control pathways than normal cells. The proteasome is a critical component of the protein quality control machinery. ...

Role Of Integrin-Linked Kinase In Synaptic Plasticity And Memory:o Diabetes/Alzheimer’s Link

Ali, Engy (2012-05-03)

Type 2 diabetes mellitus (T2DM) has recently been proven to be a risk factor for cognitive dysfunction and dementia such as Alzheimer’s disease (AD). However, the exact pathophysiology of cognitive dysfunction in patients ...