Browsing by Author "DeRuiter, Jack"

Now showing items 1-13 of 13

Applications of Mass spectrometry in natural product drug discovery for malaria: Targeting Plasmodium falciparum thioredoxin reductase

Munigunti, Ranjith (2013-04-23)

Malaria is considered to be the dominant cause of death in low income countries especially in Africa. Malaria caused by Plasmodium falciparum is a most lethal form of the disease because of its rapid spread and the development ...

Chromatographic and Mass Spectral Studies on Mass Equivalent Substituted Phenethlamines Related to MDEA, MDMMA and MBDB

Thigpen, Ashley (2006-12-15)

The goal of this project is to evaluate the GC-MS properties of a series of twelve regioisomeric and isobaric ring substituted phenethylamines with identical molecular weight and major fragmentation ions. Three regioisomeric ...

Computational Modeling, Design and Synthesis of Selective Cannabinoid Receptor 2 (CB2) Agonists

Neel, Logan (2021-12-08)

Synthetic cannabinoids that are synthesized and used recreationally are a world-wide health problem. They are synthesized in order to mimic the euphoric effects similar to THC, but due to the higher affinity at the cannabinoid ...

Discovery and characterization of synthetic and natural compounds as inhibitors of shikimate kinase from Mycobacterium tuberculosis by LC-MS

Simithy, Johayra (2014-12-10)

With the increasing emergence of drug-resistant tuberculosis (TB) and the complication by HIV co-infection, Mycobacterium tuberculosis (Mtb) remains a challenging target for drug discovery. The shikimate pathway, responsible ...

Establishment and optimization of the LC-MS-based strategy for screening of passively absorbed açaí and maca constituents for CYP3A4 inhibition

Rants'o, Thankhoe Abram (2017-07-27)

The escalation of cancer morbidity and mortality has increased the use of botanical dietary supplements among cancer patients undergoing chemotherapy. Euterpe oleracea Mart. (açaí) berry and Lepidium meyenii Walpers (maca) ...

LC-MS based characterization of Mycobacterium tuberculosis shikimate kinase inhibitors containing oxadiazole-amide and aminobenzothiazole rings

Alturki, Mansour (2016-07-26)

The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has increased the demand for the discovery of new antitubercular drugs. The shikimate pathway is essential ...

LC-MS based metabolite fingerprinting and profiling of a traditional Chinese medicine YANG XIN® formulation

Almalki, Ahmad (2015-07-29)

For thousands of years, Traditional Chinese Medicine (TCM) has been used to treat or prevent various diseases, for this reason western countries have been attracted to and use TCM together with allopathic medicine. YANG ...

Mass Spectral and Chromatographic Studies on a Series Of Regioisomers and Isobaric Derivatives Related to Methylenedioxymethamphetamines

Awad, Tamer (2006-12-15)

The popular drug of abuse 3,4-methylenedioxymethamphetamine (MDMA) has regioisomeric and isobaric substances of mass equivalence, which have similar analytical properties and thus the potential for misidentification. Direct ...

Mass Spectral, Infrared and Chromatographic Studies on Designer Drugs of the Piperazine Class

Hafiz Abdel-Hay, Karim (2012-02-20)

The controlled drug 3,4-methylenedioxybenzylpiperazine (3,4-MDBP) has regioisomeric and isobaric substances of mass equivalence, which have similar analytical properties and thus the potential for misidentification. The ...

Revalidating DNA Damage Inducible 1 Homolog II (DDI2) as a Novel Target for the Treatment of Cancer

Ibtisam, Ibtisam (2023-05-04)

Cancer cells are under proteotoxic stress and are more sensitive to the perturbation of protein quality control pathways than normal cells. The proteasome is a critical component of the protein quality control machinery. ...

Strategies for Monitoring Pathologic Conditions and Treatment Efficacy in Murine Models

Brannen, Andrew (2016-12-09)

On the surface, the pathologies of infectious disease and cancer appear fundamentally different; however, there exist several commonalities including pharmacological targets and resistance mechanisms, immune response, and ...

Synthesis, Analytical Profiles and Receptor Pharmacology of Methoxylated Derivatives and Regioisomers of the NBOMe series of Hallucinogenic Drugs

Almalki, Ahmad (2019-04-23)

The potential for designer analogue development in the NBOMe series of drugs of abuse is very high based on the methods used to synthesize this class of compounds, and the availability of a wide variety of precursor ...

Synthesis, GC–MS, GC–MS/MS, GC–IR and chromatographic studies on cathinone derivatives related to methylenedioxypyrovalerone (MDPV)

Abiedalla, Younis (2018-12-03)

This project will address issues of resolution and discriminatory capabilities for cathinone derivatives (regioisomeric and homologous groups) providing additional reliability and selectivity for forensic evidence and ...