- AUETD Home
- Browsing by Author
Browsing by Author "Dhanasekaran, Murali"
Now showing items 1-9 of 9
- Sort by:
- title
- issue date
- submit date
- Order:
- ascending
- descending
- Results:
- 5
- 10
- 20
- 40
- 60
- 80
- 100
Elucidating the Cognitive Deficits following Doxorubicin treatment
Alhowail, Ahmad (2014-12-11)
Chemotherapeutic drugs are effective in the treatment of various types of tumors;
however, the optimal clinical effectiveness is limited due to secondary effects including
cognitive impairment, also known as “chemobrain”, ...
Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling
Darakjian, Lucy (2020-05-14)
In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...
Identification of A New Pharmacological Modulator for P2Y2 Receptor Activity
Alsadah, Eiman (2018-04-23)
P2Y2 is a G-protein-coupled membrane receptor activated by ATP or UTP nucleotides. They play major roles in cellular physiology in different aspects including inflammatory responses and apoptosis. Therefore, P2Y2 receptor ...
Illuminating the Neurotoxic Effects of TFMPP derivatives in N27 Rat Dopaminergic Neuronal Cells through Oxidative Stress and Mitochondrial Dysfunction
Majrashi, Mohammed (2017-05-03)
The use of designer drugs in the United States have increased tremendously. Designer drugs
are highly dangerous and most importantly the abusers don't have a clue with regard to what they
are getting. Thus, it is currently ...
Investigate the Effects of Designer Drugs on Amyloid Beta
Harshan, Aishah (2020-07-15)
Designer drugs are structurally novel compounds that can exhibit several pharmacodynamic effects. The diverse pharmacodynamic effects of designer drugs are due to their significant interaction with the major drug targets ...
Molecular Mechanisms Regulating Hepatic Fetuin-A Expression
Kothari, Vishal (2016-12-05)
Fetuin-A (Fet-A) is a hepatokine, known to inhibit insulin signaling and is associated with diabetes, cardiovascular outcomes and inflammation. Post-translational modification of fetuin-A at different glycosylation and ...
Nicotine and Integrin Linked Kinase Interplay Modulates Synaptic Plasticity Mechanisms Required for Memory
Aljadani, Fatimah (2015-09-23)
Integrin Linked Kinase (ILK) has been associated with forms of synaptic plasticity required for memory. Nicotine, at low-concentration improves memory but higher concentrations impart learning and memory deficits. The ...
Role of Chemokine Receptor CXCR7 in Adipocyte Physiology and Disease
Shi, Yi (2022-04-14) ETD File Embargoed
Objective—Chemokines and chemokine receptors have long been shown to play important roles in inflammation, obesity, and type II diabetes. CXCR7 is characterized as an atypical chemokine receptor whose function as a signaling ...
Role Of Integrin-Linked Kinase In Synaptic Plasticity And Memory:o Diabetes/Alzheimer’s Link
Ali, Engy (2012-05-03)
Type 2 diabetes mellitus (T2DM) has recently been proven to be a risk factor for cognitive dysfunction and dementia such as Alzheimer’s disease (AD). However, the exact pathophysiology of cognitive dysfunction in patients ...