Browsing by Author "Dhanasekaran, Muralikrishnan"

Now showing items 1-19 of 19

Adiponectin alters hippocampal synaptic function: a mechanism for amelioration of synaptic deficits in a mouse model of Alzheimer’s disease

Bloemer, Jenna (2019-12-06)

The hormone adiponectin, the most abundant adipokine, is an important regulator of metabolic function, and recent evidence suggests that adiponectin plays an essential role in the cross-talk between adipose tissue and brain ...

Computational Modeling, Design and Synthesis of Selective Cannabinoid Receptor 2 (CB2) Agonists

Neel, Logan (2021-12-08)

Synthetic cannabinoids that are synthesized and used recreationally are a world-wide health problem. They are synthesized in order to mimic the euphoric effects similar to THC, but due to the higher affinity at the cannabinoid ...

Differential Modulation of Glutamatergic Synaptic Transmission by Polysialic Acid

Sims, Catrina (2007-12-15)

Controlled modulation and regulation of glutamate receptors are essential for synaptogenesis and synaptic plasticity. The two major types of excitatory glutamate receptors found at the synapse are AMPA and NMDA, which ...

Effects of Piperazine Derivatives on Hippocampal and Dopaminergic Neurotransmission

Majrashi, Mohammed (2019-10-08) ETD File Embargoed

Designer Drugs are a group of psychoactive substances synthesized from chemicals to emulate the pharmacodynamic and pharmacokinetic actions of widely used substances of abuse. A minor modification of the chemical structure ...

Elucidate the Neuro-Pharmacodynamic Actions of 3-Hydroxypterostilbene

Kadannagari, Surekha (2022-11-29)

Pterostilbene (dimethyl ether analog of resveratrol) is a metabolically stable natural bioactive and has exhibited substantial pharmacological activities. 3-Hydroxypterostilbene is a natural pterostilbene analog and an ...

Elucidating the dopaminergic neurotoxicity of kainic acid

Alghenaim, Fada (2020-08-21)

Dopamine is an essential catecholamine neurotransmitter in the central and peripheral nervous system. This monoaminergic neurotransmitters is required for the maintenance of several physiological functions (control of ...

Elucidating the Neurotoxic Effects of Piperazine Derivatives in Human Neuroblastoma Cells through Oxidative Stress, Mitochondrial Dysfunction and Apoptosis

Katz, Daniel (2015-07-24)

Designer drugs are synthetic structural analogues/congeners of controlled substances with slightly modified chemical structures intended to mimic the pharmacological effects of known drugs of abuse so as to evade drug ...

Elucidating the Role of Integrin Linked Kinase Pathway in Moderate Drinking Prenatal Alcohol Exposed Rat Model

Bhattacharya, Dwipayan (2015-11-18)

Alcohol and nicotine are well known teratogen which has been reported to have large scale effect on developing fetus. Prenatal alcohol cause many deleterious effect during fetal development which either persist throughout ...

Environmental Toxins and Dopaminergic Neurotoxicity: Novel Neuroprotective Strategies

Karuppagounder, Senthilkumar (2009-08-07)

Parkinson's disease (PD) is a progressive degeneration of dopaminergic neurons in the substantia nigra, leading to massive loss of dopamine in the striatum. Environmental and endogenous neurotoxins are implicated the ...

Evaluating the dopaminergic neurotoxic effects of chemotherapeutics

Desai, Darshini (2018-04-30)

Chemotherapy-induced neurotoxicity is one of the most common contraindication seen in the cancer survivors. Thus chemotherapy-induced neurotoxicity can adversely affect the clinical management of these patients. Cancer ...

Evaluation of Toxicity Levels and Cytotoxicity Mechanisms of Corexit 9500

Zheng, Mengyuan (2013-07-15)

The 2010 British Petroleum (BP) oil spill in the Gulf of Mexico has raised many ecological and health concerns. BP predominately used Corexit9500A to disperse crude oil in the Gulf of Mexico to prevent shoreline contamination. ...

Investigate the dopaminergic neurotoxicity profile of designer drugs (Piperazine derivatives)

Almaghrabi, Mohammed (2018-05-14)

Different botanical derived, or synthetic addictive substances have been “misused” and/or “abused” for centuries around the world. To overcome the abuse by these substances, strict legal laws were constituted globally. ...

Lysophosphatidic Acid Induces Tau Hyperphosphorylation by Dysregulation of Kinase and Phosphatases

Ramesh, Sindhu (2022-12-08) ETD File Embargoed

The increased incidence of Alzheimer’s disease (AD) indicates an unmet medical need to develop novel molecular targets for therapeutic potential. Alzheimer’s disease is primarily classified into early-onset (genetic) and ...

Molecular Mechanisms of Neuroprotection by an Alternative Drug Scutellaria lateriflora

Lohani, Madhukar (2014-07-21)

Anxiety is one of the most prevalent neuropsychological disorders around the world. In the United States of America (USA), it is a serious health problem affecting a large number of people and is considered as one of the ...

Neuroprotection against Methamphetamine Induced Neurotoxicity: Applications for Parkinson’s Disease

Thrash, Bessy (2009-05-04)

Parkinson’s disease is a progressive neurodegenerative disorder associated with selective degeneration of nigrostriatal dopaminergic neurons. It is the most common of the neurodegenerative movement disorders, affecting ...

Phosphodiesterase 5 Inhibition on Dopaminergic and Glutamatergic Neurotransmission: Implications for Memory Enhancement

Uthayathas , Subramaniam (2009-02-06)

Phosphodiesterases belongs to a family of proteins that metabolize cyclic nucleotides. There are at present eleven types of Phosphodiesterases been isolated and shown to be expressed in various tissues. Phosphodiesterase ...

Prenatal Nicotine Exposure and Molecular Mechanisms of Memory Impairment

Parameshwaran, Kodeeswaran (2008-08-15)

Prenatal nicotine exposure in the form of active maternal smoking is a major risk factor for several harmful effects in the children. These effects include reduced motor skills, poor IQ scores and most importantly learning ...

Synthesis, Analysis, and Pharmacological Profile of Designer Piperazine Drugs

Almaghrabi, Mohammed (2021-06-14)

New or novel Psychoactive substances (NPS) or designer drugs are often uncontrolled synthetic chemicals that are analogs to classic controlled substances and have been a public health threat in the last two decades. The ...

Three-dimensional Printing of Drug-eluting Implants and Orodispersible Films

Annaji, Manjusha (2023-09-25) ETD File Embargoed

Three-dimensional (3D) printing is a rapidly emerging additive manufacturing technology utilized to quickly fabricate customized dosage forms with complex geometrical designs. Due to its flexibility in adjusting the dose, ...