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Browsing by Author "Li, Feng"

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Determine the Anticancer Activity and Mechanism of Overcoming Drug Resistance by Cu(DDC)2 NPs in Prostate Cancers 

Wang, Junwei (2021-07-14)  ETD File Embargoed
Copper diethyldithiocarbamate [Cu(DDC)2] complex formed by disulfiram (DSF) and copper ions is a promising therapeutic agent for cancer treatment. However, the poor aqueous solubility of Cu(DDC)2 limited its clinical ...

Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling 

Darakjian, Lucy (2020-05-14)
In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...

Nanoparticles-based Drug Delivery Systems for Resistant Cancer Treatment 

Chen, Wu (2021-11-29)  ETD File Embargoed
Many FDA-approved drugs have been repurposed as anticancer agents to fulfill the increasing demand for more effective anti-cancer drugs especially for drug-resistant cancers. Disulfiram (DSF) is an FDA-approved drug which ...

Plasmonic nanomaterials for label-free biosensor towards next-generation point-of-care immunoassay 

He, Jiacheng (2021-11-12)
Cytokines, a broad category of low molecular weight signaling proteins, are key immune modulators for cell-based immune response. An abnormal level of cytokine can lead to acute/chronic inflammation, multiple organ failure, ...