Browsing by Author "Lipke, Elizabeth"

Now showing items 1-14 of 14

Bioinspired Microphysiological Systems for in vitro Elucidation of Prostate Tumorigenic Progression and Application in Pre-clinical Therapeutic Evaluation

Habbit, Nicole (2022-12-05) ETD File Embargoed

Contrary to conventional belief, prostate cancer tumors are not merely uniform clusters of cancerous cells that undergo uncontrollable growth and migrate indiscriminately throughout the body. Instead, the prostatic tumor ...

Creating a 3D Stem Cell Microenvironment to Produce Human Developing Cardiac Tissues for Scale-Up and Disease Modeling

Kerscher, Petra (2016-08-03)

In the field of tissue engineering, the use of human induced pluripotent stem cells (hiPSCs) has proven extremely valuable based on their ability to differentiate into almost any cell type within the human body, but keep ...

Culture and Characterization of Endothelial Colony Forming Cells from Peripheral Blood, Bone Marrow, and Umbilical Cord Blood of Horses

Salter, Margaret (2014-05-02)

Endothelial progenitors cells (EPCs), are a type of progenitor cell originating in the bone marrow and can be found circulating in peripheral blood, bone marrow, and umbilical cord blood. EPCs play an essential role in ...

Development of Biomimetic Materials for Enhanced Maturation of Engineered Cardiac Tissue

Hodge, Alexander (2016-05-06)

The creation of cardiac tissue constructs holds potential in the development of clinical and diagnostic platforms, including the creation of novel treatments for patients with heart disease and cost-effective platforms for ...

Differentiation of Mouse Embryonic Stem Cells Using PEG-Fibrinogen Hydrogel Microspheres

Chang, Samuel (2012-05-15)

Cardiac disease is the leading cause of death worldwide, and current treatments are either ineffective at significantly prolonging lifespan or are unavailable to the majority of patients in need due to a lack of supply. ...

Engineered Colorectal Cancer Tissues Employing Patient-derived Cells for Recapitulating the Tumor Microenvironment

Hassani, Iman (2021-04-21) ETD File Embargoed

Colorectal cancer (CRC) remains the third most prevalent cancer and the third-highest cause of cancer-related deaths among both men and women in the United States. The development of pre-clinical CRC models is vital for ...

Establishment of 3D hiPSC cardiac differentiation platforms to investigate congenital heart disease

Ellis, Morgan (2021-04-19) ETD File Embargoed

Cardiac tissue engineering shows great potential for alleviating some of the immense burden of cardiovascular disease. The introduction of human induced pluripotent stem cells (hiPSCs) in 2007 led to a paradigm shift in ...

Poly(ethylene glycol)-based Hydrogel to Support Endothelialization and Vascularization by Endothelial Progenitor Cells

Seeto, Wen (2014-12-04)

Endothelial progenitor cells (EPCs) have the potential to become a reliable source of autologous cells for endothelialization of intravascular devices and vascularization of tissue engineered constructs. Endothelial colony ...

Poly(ethylene glycol)-Based Hydrogels to Support Vascularization and Reendothelialization by Endothelial Colony Forming Cells

Tian, Yuan (2020-03-16)

Endothelial colony forming cells (ECFCs) have a high proliferative capability and can differentiate into endothelial cells, making them a promising cell source for vascularization of ischemic tissues and reendothelialization ...

Production of Engineered Cardiac Tissue from Encapsulated hiPSCs for Scale-up Studies and Drug-Testing

Finklea, Ferdous (2021-04-19) ETD File Embargoed

Cardiovascular disease is the leading cause of death worldwide, causing a global health and financial burden. The first chapter of this dissertation highlights the needs for scalable, clinically relevant production of human ...

Size Optimization of Magnetic Nanoparticles for Biomedical Applications via a Novel Size- Selective Fractionation Process

Rogers, Hunter (2014-12-12)

Magnetic nanoparticles, especially those composed of iron oxide, are extremely attractive options when it comes to MRI contrast agents and magnetically targeted therapies. Their superparamagnetic properties as well as their ...