Browsing by Author "Livant, Peter"

Now showing items 1-14 of 14

Carbocyclic C-Nucleosides Derived from Formycin

He, Mingzhu (2008-12-15)

Analogs of naturally occurring nucleosides have served as structural models for the design of antitumor, antiviral, and antibacterial agents. Some modified nucleosides have become major therapeutic agents for the treatment ...

Design and Properties of Novel Uranium-Containing Layered and Framework Materials

Shvareva, Tatiana (2006-12-15)

Ten uranyl-containing frameworks and one layered material have been synthesized under hydrothermal conditions. These compounds belong to eight structure types, not previously described. They are constructed from uranyl ...

Design and Synthesis of AdoHcy Hydrolase Inhibitors as a Source of Antiviral Agents

Liu, Chong (2008-05-15)

The significant antiviral properties of the carbocyclic nucleosides aristeromycin and neplanocin A have been attributed to inhibition of AdoHcy hydrolase, which in turn affects viral mRNA capping methylation. However, their ...

The Identification of Critical Active-Site Groups and Catalytic Steps Governing the Desulfonation Reaction by Alkanesulfonate Monooxygenase

Robbins, John (2012-10-08)

The alkanesulfonate monooxygenase enzyme (SsuD) catalyzes the oxygenolytic cleavage of a carbon-sulfur bond of sulfonated substrates. A mechanism involving acid-base catalysis is proposed for the desulfonation mechanism ...

Microwave Promoted Addition of Organosiloxanes to Hydroxyl Containing Substrates for Facile Synthesis of Chemical and Biological Warfare Agent Reactive Polymers

Owens, Jeffery (2007-05-15)

The primary focus of this work was the synthesis and characterization of materials efficacious in detoxifying/killing chemical and/or biological threat agent surrogates, including Bacillus anthracis spores, in militarily ...

New Dendrimers and Lipids Based on 2,2′-Bi(glycerol), and Lewis Acid Dependent Rearrangements of a Protected Pinacol

Pulsani, Kavitha (2017-04-25)

Chapter 1: 2,2'-Bi(glycerol), or 2,3-bis(hydroxymethyl)butane-1,2,3,4-tetraol is of interest because of its utility as a potential A6 core for novel dendrimers, and because it may lead to hitherto un¬known 2,2'-bi(triglyceride)s ...

QM/MM/MC Simulations for the Elucidation of Ionic Liquid Solvent Effects upon Organic Reactions

Allen, Caley (2013-04-30)

The research in this dissertation is focused on elucidating and understanding ionic liquid solvent effects on classical organic reactions. Ionic liquids are an exciting class of solvents that have attracted the attention ...

Regioselectivity of the Photoisomerization of Acyclic 1,3-Dienes and Stable Trans Cycloheptenes

Ruychev, Veselin (2012-12-05)

There is still no complete understanding of how the visual system controls the regioselectivity of the photoisomerization of the C11=C12 double bond in the visual chromophore retinal. In this work we used a series of ...

Seeking MRNA Methylation Inhibitors as Antiviral Agents

Li, Weikuan (2008-08-15)

Aristeromycin and neplanocin A are two examples of potent S-adenosylhomocysteine hydrolase inhibitors. As a consequence, they show significant broad-spectrum antiviral activity, however, their clinical potential is limited ...

Synthesis and Characterization of New Lanthanide Chalcogenides

Jin, Gengbang (2007-08-15)

A large number of new ternary and quaternary lanthanide chalcogenides have been synthesized through solid-state reactions of corresponding elements with the aid of alkali metal halides and Sb2Q3 (Q = S, Se) fluxes. Molten ...

Synthesis of a Congested Heptamine as a Potential Precursor to Hypervalent (10-n-5) Nitrogen, and Effects of Remote Substituents on Planarization of Nitrogen in Trialkylamines

Makhanu, David (2012-05-16)

The challenging synthesis of a congested heptamine 10, as a potential precursor to hypervalent (10-N-5) nitrogen, was pursued by employing four different strategies. Even though these strategies didn’t lead to a successful ...

Synthetic Explorations to Sinefungin Analogs

Zhao, Guoxia (2009-05-15)

Sinefungin, a natural complex nucleoside, has been isolated from the cultures of Streptomyces griseolous, and from that of Streptomyces incarnatus. It is a structural analog of S-adenosylmethionine (AdoMet) and since its ...

Toward a Breathable Fabric for Protection Against Airborne Toxic Chemicals, and an Olefin-Forming Cascade Reaction En Route to 2,2’-Bi(glycerol)

Li, Xiaoxun (2009-07-31)

Part I. Several compounds that were envisioned to interact strongly with airborne chemical warfare agents, principally organophosphorus nerve agents, were synthesized. This was part of a multi-site, multi-investigator ...

Tris(1,3-Dihydroxy-2-propyl)amine, A Planar Trialkylamine: Synthesis, Structure, and Properties. A Potential Precursor to Hypervalent Nitrogen

Jie, Yuanping (2006-05-15)

The hindered amine tris(1,3-dihydroxy-2-propyl)amine, 36, is a potential precursor to possible examples of nitrogen hypervalency. There are no simple, effective, and general methods to synthesize hindered tertiary amines. ...