Browsing by Author "Martin, Douglas"

Now showing items 1-9 of 9

Bony Abnormalities in Feline Models of GM2 Gangliosidosis

Beadlescomb, Patricia (2014-07-09)

This study seeks to explore and quantify bony deformities in feline models affected with GM2 gangliosidosis with emphasis on long bones and cervical vertebrae, based on previous diagnostics exhibiting cervical spinal cord ...

Gene Therapy Approaches for Neurological Lysosomal Storage Diseases

McCurdy, Victoria (2014-04-25)

GM1 and GM2 gangliosidosis are lysosomal storage diseases caused by deficiency of enzymes required for ganglioside catabolism. Enzyme deficiencies cause neuronal accumulation of ganglioside resulting in progressive ...

Gonadotropin-releasing Hormone Receptor As A Molecular Target for Contraception in Feral Cats

Napier, India (2015-12-10)

The global overpopulation of feral cats generates concern regarding their welfare, negative impact on public health, and adverse effects on the environment. In the U.S. and other Westernized countries, the most common ...

Immunomodulatory Effects of Intracranial Gene Therapy in Feline Sandhoff Disease

Bradbury, Allison (2014-05-02)

Sandhoff disease (SD) is a lysosomal storage disorder characterized by absence of hydrolytic enzyme β-N-acetylhexosaminidase (Hex), which results in storage of GM2 ganglioside in neurons and unremitting neurodegeneration. ...

Minimally invasive routes of AAV administration to treat GM1 gangliosidosis

Gross, Amanda (2020-04-17)

GM1 gangliosidosis is a lysosomal storage disease caused by a deficiency of lysosomal β-galactosidase (βgal), which results in the accumulation of GM1 ganglioside and fatal neurodegeneration. In the human type II (late ...

Multilevel Targeting of Canine Adenovirus Type 2 (CAV2) to Expand Oncolytic Virotherapy in Canine Tumors

Sajib, Abdul Mohin (2020-04-06)

Oncolytic virotherapy is a promising therapeutic approach designed to selectively eradicate cancer cells but to spare normal cells. Oncolytic adenoviruses (Ad) are an outstanding and common vehicle for efficient cancer ...

Myelin Deficits and Intravenous Gene Therapy in Feline Sandhoff Disease

Maguire, Anne (2021-07-27)

Sandhoff Disease (SD) is a neurodegenerative lysosomal storage disease (LSD) that results in the death of children before 4 years of age. Because there are no FDA-approved therapies available, current treatment strategies ...

Phage-GnRH Constructs for Population Control of Feral Animals: Evaluation in Cats

Jones, Rebecca (2018-11-15)

The overpopulation of cats is a problem in the United States and worldwide due to public health concerns and their role as a predator of wildlife species. The focus of this research is the development of anti-fertility ...

Tunable Polymersomes: Towards Enzyme Delivery Through the Blood-Brain Barrier

Kelly, Jessica (2017-04-26)

Delivery of therapeutics to the brain through non-invasive administration is a difficult task due to the blood-brain barrier (BBB), which prevents the transport of 98% of therapeutics. In GM1 gangliosidosis, patients are ...