Browsing by Author "Panizzi, Peter"

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Assessment of Tofacitinib and Ruxolitinib and their Anti Inflammatory Effects on Myeloperoxidase

Milton, Amber (2017-07-27)

Abstract Myeloperoxidase (Mpo) is a heme-containing enzyme present in inflammation. Mpo catalyzes the production of hypochlorous acid (HCLO) by reacting with hydrogen peroxide (H2O2) and chloride (Cl-). Mpo together ...

Clinical Pharmacokinetic Analysis and Modeling of Tranexamic Acid in Dogs

Almoslem, Mohammed (2018-05-30)

Tranexamic Acid (TXA) is an FDA approved drug for hemophilia patients undergoing dental extractions and women experiencing heavy bleeding during menstrual periods. It is also used to stop bleeding and decrease risk of ...

Cloning and characterization of novel ccdc103 interactors

Daniel, Jeffrey (2020-07-16) ETD File Embargoed

Coiled-coil domain containing protein 103 is a homodimeric protein that functions as a dynein attachment factor in motile cilia. Ccdc103 defects in zebrafish (Danio rerio) embryos lead to paralyzed motile cilia, pronephric ...

Deep tissue imaging of B16 melanoma in mice by Multispectral Optoacoustic Tomography

Bahauddin, Ammar (2022-06-23) ETD File Embargoed

Melanoma is an aggressive type of skin cancer that can metastasize to draining lymph nodes and distant organs. Early detection of melanoma holds the promise of improved patient outcomes by enabling earlier surgical ...

Design and Analysis of Low-Cost X-Ray Imaging System Incorporating Add-On Mouse Rotation System in Pre-Clinical Research

Zhou, Huanyi (2022-07-21)

Computed tomography (CT) has become an essential tool in diagnostic and sports medicine. It is able to generate a three-dimensional rendering that can be used to interrogate a given region or desired structure from any ...

Discovery, expression, and characterization of biosynthetic gene clusters encoding antimicrobial secondary metabolites from a soil metagenome and cultured Actinobacteria

Sandoval-Powers, Megan (2022-07-19)

Dating back to the discovery of penicillin in 1928, nature and its diverse microbial life has been the most prolific source of antimicrobial compounds. These bioactive compounds are often derived from microbial secondary ...

Effect of Extended Exposure Topotecan on Drug Resistance Using a Novel 3D Spheroidal Model of Castrate-Resistant Prostate Cancer

Davis, Joshua (2023-04-24)

Cancer consistently commands the highest number of therapeutic drug approvals each year, however, this has yet to yield significant clinical benefits for metastatic disease. Instead, most drugs are likely to increase ...

High Quality CT Image Reconstruction from Limited Projections Obtained from MiSpinner

Zhou, Huanyi (2016-05-05)

Computed tomography (CT) technology is widely used in the medical and industrial fields. However, a traditional CT machine costs too much for many researchers to afford it and prevents them from doing related research. To ...

Identification and Characterization of Molecular Correlates of Disease in Invasive Streptococcus and Staphylococcus Infection Models

Davis, Richard IV (2015-07-29)

Invasion into the host vasculature marks a dangerous, and often times fatal, complication of bacterial infections. One such severely invasive bacterium, Streptococcus pyogenes, is estimated to affect 18 million people ...

Mechanisms Underlying Myeloperoxidase Inhibition: Evaluating the Efficacy and Safety of Anti-inflammatory MPO Inhibitors Designed to Limit the Generation of Reactive Oxygen and Nitrogen Species

Huang, Jiansheng (2015-07-24)

Myeloperoxidase (MPO), a heme-containing peroxidase, plays a critical role in the innate immune response by producing hypochlorous acid. MPO-mediated oxidation is also associated with chronic obstructive pulmonary disease ...

Real-time Monitoring of Staphylococcus Aureus Biofilm Formation Under Flow Conditions in Microfluidic Chambers

Al Mouslem, Abdulaziz Khalid (2020-07-21) ETD File Embargoed

Staphylococcus aureus (S. aureus) causes most of life-threatening infections such as endocarditis, osteomyelitis and sepsis. Since biofilm development is often a key factor in the development of an infection of indwelling ...

Role of Chemokine Receptor CXCR7 in Adipocyte Physiology and Disease

Shi, Yi (2022-04-14) ETD File Embargoed

Objective—Chemokines and chemokine receptors have long been shown to play important roles in inflammation, obesity, and type II diabetes. CXCR7 is characterized as an atypical chemokine receptor whose function as a signaling ...

Staphylococcal and Streptococcal Biotechnology: Utilization of Bacterial Tools to Advance Preclinical Research and Healthcare

Muse, Charlotte (2023-08-03) ETD File Embargoed

Existing within microcosms of their own making, bacteria sculpt the surrounding environment by responding to the current climate or altering their habitat for protection and survival. The net effect of the bacterium’s ...