Browsing by Author "Parish, Edward"

Now showing items 1-15 of 15

8-Alkyl Adenines and Their Nucleoside Derivatives

Abouelghit, Maha (2011-07-28)

S-adenosylhomocysteine hydrolase has become an important target in the design of antiviral drugs. It is the only known enzyme in eukaryotes that is responsible for the catabolism of S-adenosylhomocysteine into adenosine ...

Allylic Oxidation of Steroidal Compounds Using Vanadyl Acetylacetonate and Tert-butyl Hydroperoxide

Grainger, Wendell (2015-07-29)

Allylic oxidation is an important reaction in steroid chemistry. Previously reported methods have various limits which do not apply when using vanadyl acetylacetonate and tert-butyl hydroperoxide. These limits include ...

Carbocyclic C-Nucleosides Derived from Formycin

He, Mingzhu (2008-12-15)

Analogs of naturally occurring nucleosides have served as structural models for the design of antitumor, antiviral, and antibacterial agents. Some modified nucleosides have become major therapeutic agents for the treatment ...

Comparative Study of Gravid-Trap Infusions for Capturing Blood-Fed Mosquitoes (Diptera: Culicidae) of the Genera Aedes, Ochlerotatus, and Culex

Burkett, Nathan (2005-08-15)

Field experiments were conducted in east-central Alabama to compare the attractiveness of selected gravid-trap infusions to ovipositing female mosquitoes of 3 medically important genera: Aedes, Ochlerotatus and Culex. ...

Design and Synthesis of AdoHcy Hydrolase Inhibitors as a Source of Antiviral Agents

Liu, Chong (2008-05-15)

The significant antiviral properties of the carbocyclic nucleosides aristeromycin and neplanocin A have been attributed to inhibition of AdoHcy hydrolase, which in turn affects viral mRNA capping methylation. However, their ...

Exploring actinide chemistry: uranyl detection and thorium catalysis

Tutson, Charmaine (2017-04-21)

In a world where there is a strong need to improve our means of producing energy to sustain our ever expanding population with low green-house emissions, nuclear power offers sustainability and low greenhouse emissions, ...

Isoprenoid synthesis: New roles for iron sulfur clusters

Adedeji, Dolapo (2007-08-15)

Spectroscopic investigations of the GcpE and LytB enzymes involved in the last two steps of the DOXP pathway for isoprene synthesis have been described. YfgB, one of the accessory proteins has also been characterized. ...

Microwave Promoted Addition of Organosiloxanes to Hydroxyl Containing Substrates for Facile Synthesis of Chemical and Biological Warfare Agent Reactive Polymers

Owens, Jeffery (2007-05-15)

The primary focus of this work was the synthesis and characterization of materials efficacious in detoxifying/killing chemical and/or biological threat agent surrogates, including Bacillus anthracis spores, in militarily ...

Probing the Reaction Mechanism of Methyl Coenzyme M Reductase

Wang, Mi (2008-08-15)

Methyl coenzyme M reductase (MCR) is the key enzyme in both microbial methane production and anaerobic methane oxidation. MCR catalyzes the reaction of methyl-coenzyme M (CH3SCoM) and coenzyme B (HSCoB) to methane and the ...

Studies on The Synthesis of B-Ring 6-Azasteroids

Gandikota, Jyothi (2006-08-15)

Azasteroids, which carry a nitrogen in the C-6 position of the steroid nucleus are still mysterious and very few synthesized, were found to possess antimicrobial and antifungal properties apart from their pharmacodynamic ...

The Synthesis and Practical Applications of Novel N-Halamine Biocides

Barnes, Paul (2006-12-15)

A novel set of N-halamine siloxane precursors were synthesized for the purpose of coating various substrates to determine the factors, which are the most dominant influences of the overall stability of the newly modified ...

Synthetic Explorations to Sinefungin Analogs

Zhao, Guoxia (2009-05-15)

Sinefungin, a natural complex nucleoside, has been isolated from the cultures of Streptomyces griseolous, and from that of Streptomyces incarnatus. It is a structural analog of S-adenosylmethionine (AdoMet) and since its ...

Toward a Breathable Fabric for Protection Against Airborne Toxic Chemicals, and an Olefin-Forming Cascade Reaction En Route to 2,2’-Bi(glycerol)

Li, Xiaoxun (2009-07-31)

Part I. Several compounds that were envisioned to interact strongly with airborne chemical warfare agents, principally organophosphorus nerve agents, were synthesized. This was part of a multi-site, multi-investigator ...

Towards a Bistable Nucleic Acid-Directed Switch for Electrochemical Readout of Proximity Ligation Assays

Ford, Katarena (2017-01-04)

The work presented in this thesis is focused on the development of a bistable DNA-driven assay formatted for biosensor applications in biological research, medical research, and an approach to point-of-care testing. We ...

Tris(1,3-Dihydroxy-2-propyl)amine, A Planar Trialkylamine: Synthesis, Structure, and Properties. A Potential Precursor to Hypervalent Nitrogen

Jie, Yuanping (2006-05-15)

The hindered amine tris(1,3-dihydroxy-2-propyl)amine, 36, is a potential precursor to possible examples of nitrogen hypervalency. There are no simple, effective, and general methods to synthesize hindered tertiary amines. ...